PMID- 22431406
OWN - NLM
STAT- MEDLINE
DCOM- 20120720
LR  - 20220408
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 14
IP  - 4
DP  - 2012 Apr
TI  - Cognitive function in patients with decompensated heart failure: the Cognitive 
      Impairment in Heart Failure (CogImpair-HF) study.
PG  - 404-13
LID - 10.1093/eurjhf/hfs015 [doi]
AB  - AIMS: The objective of this study was to examine cognitive and psychological 
      processes systematically in patients with decompensated chronic heart failure 
      (CHF) and to document changes in cognitive function after compensation. Executive 
      functions, episodic memory, and attention are impaired in patients with stable 
      CHF, influencing health behaviour and disease management. Cognitive function and 
      psychological co-morbidities are associated with hospitalization, disability, and 
      mortality. METHODS AND RESULTS: Cognitive performance, self-perceived quality of 
      life, and depression were compared in 20 patients with decompensated CHF 
      [ejection fraction (EF) 27 +/- 8%, N-terminal pro brain natriuretic peptide 
      (NT-proBNP) 10 880 pg/mL, interquartile range (4495-13 683)] before and after 
      compensation, 20 age- and gender-matched stable CHF patients [New York Heart 
      Association (NYHA) III-IV, EF 32 +/- 10%, NT-proBNP 1881 pg/mL (323-1502)], and 20 
      healthy controls (EF 70 +/- 5%). Patients with decompensated CHF showed 
      significantly poorer performance in terms of short-term memory, working memory, 
      executive control, and processing speed (P < 0.05) compared with stable CHF 
      patients. Compensation improved the cognitive performance of decompensated CHF 
      patients up to the level of patients with stable CHF. Compared with healthy 
      controls, both patient groups were affected with respect to episodic memory (P < 
      0.0001) and fluid intelligence (P < 0.01). CONCLUSION: Decompensated heart 
      failure patients are highly impaired in cognitive functioning, which improves but 
      does not normalize after compensation. Neuropsychological diagnostics delivers 
      important details for daily life activities and might identify individuals 
      deserving special care.
FAU - Kindermann, Ingrid
AU  - Kindermann I
AD  - Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III (Kardiologie, 
      Angiologie, Internistische Intensivmedizin), Kirrbergerstrasse, Homburg/Saar, 
      Germany. ingrid.kindermann@uks.eu
FAU - Fischer, Denise
AU  - Fischer D
FAU - Karbach, Julia
AU  - Karbach J
FAU - Link, Andreas
AU  - Link A
FAU - Walenta, Katrin
AU  - Walenta K
FAU - Barth, Christine
AU  - Barth C
FAU - Ukena, Christian
AU  - Ukena C
FAU - Mahfoud, Felix
AU  - Mahfoud F
FAU - Kollner, Volker
AU  - Kollner V
FAU - Kindermann, Michael
AU  - Kindermann M
FAU - Bohm, Michael
AU  - Bohm M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
MH  - Analysis of Variance
MH  - Chi-Square Distribution
MH  - Cognition/*physiology
MH  - Cognition Disorders/*etiology/psychology
MH  - Depression/*etiology/psychology
MH  - Female
MH  - Health Status Indicators
MH  - Heart Failure/*complications/psychology
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Quality of Life/psychology
MH  - Stroke Volume
MH  - Ventricular Function, Left
EDAT- 2012/03/21 06:00
MHDA- 2012/07/21 06:00
CRDT- 2012/03/21 06:00
PHST- 2012/03/21 06:00 [entrez]
PHST- 2012/03/21 06:00 [pubmed]
PHST- 2012/07/21 06:00 [medline]
AID - hfs015 [pii]
AID - 10.1093/eurjhf/hfs015 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2012 Apr;14(4):404-13. doi: 10.1093/eurjhf/hfs015.