PMID- 22433455
OWN - NLM
STAT- MEDLINE
DCOM- 20120516
LR  - 20141120
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 121
IP  - 2
DP  - 2012
TI  - Pulmonary arterial dilatation in pulmonary hypertension: prevalence and 
      prognostic relevance.
PG  - 76-82
LID - 10.1159/000336172 [doi]
AB  - OBJECTIVES: Pulmonary arterial dilatation is considered a consequence of chronic 
      pulmonary hypertension (PH), but despite its relatively common detection, its 
      prevalence and prognostic impact have not yet been systematically investigated. 
      The aim of the study was to investigate these factors in a relatively large 
      cohort of severe PH patients. METHODS: One hundred and forty-one consecutive 
      patients diagnosed with PH were monitored for a mean of 957 days. Data including 
      functional class, exercise capacity, invasive hemodynamics and pulmonary artery 
      (PA) echo/CT scan measurement were performed and outcomes prospectively 
      collected. RESULTS: PA dilatation is a common feature, present in the 76.6% of 
      cases in this cohort of severe PH patients. Survival at 1, 2 and 3 years was 83, 
      71 and 58%, respectively. On univariate analysis, the baseline variables 
      associated with a poor outcome were related to pulmonary arterial hypertension 
      associated with connective tissue disease (CDT-PAH), New York Heart Association 
      (NYHA) functional class, 6-min walk test and right atrial pressure. On 
      multivariate analysis only CDT-PAH and NYHA functional class remained 
      independently associated with poor survival. CONCLUSIONS: PA dilatation is 
      commonly detected in severe PH patients and is not associated with an increased 
      risk of death.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Badagliacca, Roberto
AU  - Badagliacca R
AD  - Department of Cardiovascular and Respiratory Science, I School of Medicine, 
      University of Rome Sapienza-Policlinico Umberto I, Rome, Italy. 
      roberto.badagliacca@uniroma1.it
FAU - Poscia, Roberto
AU  - Poscia R
FAU - Pezzuto, Beatrice
AU  - Pezzuto B
FAU - Papa, Silvia
AU  - Papa S
FAU - Nona, Alfred
AU  - Nona A
FAU - Mancone, Massimo
AU  - Mancone M
FAU - Mezzapesa, Mario
AU  - Mezzapesa M
FAU - Nocioni, Martina
AU  - Nocioni M
FAU - Sciomer, Susanna
AU  - Sciomer S
FAU - Valli, Gabriele
AU  - Valli G
FAU - Cedrone, Nadia
AU  - Cedrone N
FAU - Fedele, Francesco
AU  - Fedele F
FAU - Vizza, Carmine Dario
AU  - Vizza CD
LA  - eng
PT  - Journal Article
DEP - 20120315
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
SB  - IM
CIN - Cardiology. 2012;122(2):101-2; author reply 103. PMID: 22760090
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Dilatation, Pathologic/mortality/pathology/physiopathology
MH  - Familial Primary Pulmonary Hypertension
MH  - Female
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Hypertension, Pulmonary/mortality/*pathology/physiopathology
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prognosis
MH  - Young Adult
EDAT- 2012/03/22 06:00
MHDA- 2012/05/17 06:00
CRDT- 2012/03/22 06:00
PHST- 2011/09/15 00:00 [received]
PHST- 2011/12/12 00:00 [accepted]
PHST- 2012/03/22 06:00 [entrez]
PHST- 2012/03/22 06:00 [pubmed]
PHST- 2012/05/17 06:00 [medline]
AID - 000336172 [pii]
AID - 10.1159/000336172 [doi]
PST - ppublish
SO  - Cardiology. 2012;121(2):76-82. doi: 10.1159/000336172. Epub 2012 Mar 15.