PMID- 22434516
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20221207
IS  - 1559-0755 (Electronic)
IS  - 0257-277X (Linking)
VI  - 53
IP  - 1-3
DP  - 2012 Sep
TI  - Structural and functional distinctiveness of HLA-A2 allelic variants.
PG  - 182-90
LID - 10.1007/s12026-012-8295-5 [doi]
AB  - Human leukocyte antigen (HLA) class I molecules are involved in the presentation 
      of antigenic peptides to CD8(+) cytotoxic T lymphocytes (CTLs), which is 
      important for the development of cellular immunity during viral infections and in 
      cancers. HLA-A2 is one of the most frequent HLA class I specificities and thus is 
      extensively studied structurally and functionally. Since its discovery, more than 
      300 allelic variants of this HLA specificity have been recorded. Among the HLA-A2 
      allelic variants, HLA-A*02:01 is the most prevalent, hence commonly used as a 
      model to study HLA-A2-restricted CTL responses. However, HLA-A2 alleles are 
      unevenly distributed globally such that HLA-A2 allelic variants besides A*02:01 
      are expressed at considerably high frequencies in Asian and African populations. 
      Furthermore, increasing evidence of variations in the peptide-binding repertoire 
      and CTL responses among HLA-A2 allelic variants suggests the need to understand 
      these differences among various frequently expressed HLA-A2 molecules. In this 
      review, the structural and functional distinctiveness of HLA-A2 allelic variants 
      will be discussed.
FAU - Chen, Kenneth Yuanxiang
AU  - Chen KY
AD  - Singapore Immunology Network, Agency for Science, Technology and Research 
      (A*STAR), 8A Biomedical Grove, #03-06 Immunos, Singapore.
FAU - Liu, Jingxian
AU  - Liu J
FAU - Ren, Ee Chee
AU  - Ren EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Immunol Res
JT  - Immunologic research
JID - 8611087
RN  - 0 (HLA-A2 Antigen)
SB  - IM
MH  - Antigen Presentation
MH  - Asian People
MH  - Black People
MH  - Crystallization
MH  - Gene Frequency
MH  - Genetic Variation
MH  - HLA-A2 Antigen/*chemistry/*genetics/immunology
MH  - Humans
MH  - Lymphocyte Activation
MH  - Molecular Conformation
MH  - Protein Binding/immunology
MH  - Structure-Activity Relationship
MH  - T-Lymphocytes, Cytotoxic/*immunology
EDAT- 2012/03/22 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/03/22 06:00
PHST- 2012/03/22 06:00 [entrez]
PHST- 2012/03/22 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1007/s12026-012-8295-5 [doi]
PST - ppublish
SO  - Immunol Res. 2012 Sep;53(1-3):182-90. doi: 10.1007/s12026-012-8295-5.