PMID- 22435945
OWN - NLM
STAT- MEDLINE
DCOM- 20120726
LR  - 20220331
IS  - 1447-0594 (Electronic)
IS  - 1447-0594 (Linking)
VI  - 12 Suppl 1
DP  - 2012 Apr
TI  - Risk factors associated with cognitive decline in the elderly with type 2 
      diabetes: baseline data analysis of the Japanese Elderly Diabetes Intervention 
      Trial.
PG  - 103-9
LID - 10.1111/j.1447-0594.2011.00817.x [doi]
AB  - AIM: Recent evidence has shown that type 2 diabetes mellitus (T2DM) in the 
      elderly is a risk factor for cognitive dysfunction or dementia. However, the 
      precise mechanisms have not yet been elucidated. In the current study, we 
      attempted to elucidate the association of clinical indices and diabetic 
      complications at baseline with cognitive declines after 6-year follow up in type 
      2 diabetic elderly. METHODS: The subjects were 261 participants who were 
      administered the Mini-Mental State Examination (MMSE) at baseline and after 6 
      years, at the end of the observation period. The cognitive decline was determined 
      as a 5-point or greater decline in MMSE scores during the observation period. 
      Logistic regression analysis to find the factors associated with cognitive 
      decline, adjusted for age and sex, were carried out, and factors with P-values of 
      less than 0.2 were included in four models of multiple logistic regression 
      analysis. RESULTS: We found that the existence of diabetic nephropathy, higher 
      systolic blood pressure and higher serum triglycerides (or lower high-density 
      lipoprotein cholesterol) at baseline were significantly associated with cognitive 
      declines after 6 years in Japanese elderly diabetics in all four models. 
      CONCLUSION: The comorbidity of diabetic nephropathy, hypertension and 
      hypertriglyceridemia at baseline were associated with more than 5-point declines 
      in MMSE. Elucidation of the underlying mechanisms of this association is 
      warranted.
CI  - (c) 2012 Japan Geriatrics Society.
FAU - Umegaki, Hiroyuki
AU  - Umegaki H
AD  - Department of Community Healthcare and Geriatrics, Graduate School of Medicine, 
      University of Nagoya, Nagoya, Aichi, Japan. umegaki@med.nagoya-u.ac.jp
FAU - Iimuro, Satoshi
AU  - Iimuro S
FAU - Shinozaki, Tomohiro
AU  - Shinozaki T
FAU - Araki, Atsushi
AU  - Araki A
FAU - Sakurai, Takashi
AU  - Sakurai T
FAU - Iijima, Katsuya
AU  - Iijima K
FAU - Ohashi, Yasuo
AU  - Ohashi Y
FAU - Ito, Hideki
AU  - Ito H
CN  - Japanese Elderly Diabetes Intervention Trial Study Group
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Geriatr Gerontol Int
JT  - Geriatrics & gerontology international
JID - 101135738
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Aged
MH  - Blood Pressure
MH  - Cholesterol, HDL/blood
MH  - Cognition Disorders/*etiology
MH  - Diabetes Mellitus, Type 2/blood/*complications/physiopathology
MH  - Diabetic Nephropathies/complications
MH  - Diabetic Neuropathies/complications
MH  - Diabetic Retinopathy/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Risk Factors
MH  - Triglycerides/blood
FIR - Ito, Hideki
IR  - Ito H
EDAT- 2012/04/28 06:00
MHDA- 2012/07/27 06:00
CRDT- 2012/03/23 06:00
PHST- 2012/03/23 06:00 [entrez]
PHST- 2012/04/28 06:00 [pubmed]
PHST- 2012/07/27 06:00 [medline]
AID - 10.1111/j.1447-0594.2011.00817.x [doi]
PST - ppublish
SO  - Geriatr Gerontol Int. 2012 Apr;12 Suppl 1:103-9. doi: 
      10.1111/j.1447-0594.2011.00817.x.