PMID- 22437118
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20220408
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Mar-Apr
TI  - Erectile dysfunction and its association with metabolic syndrome and endothelial 
      function among patients with type 2 diabetes mellitus.
PG  - 141-7
LID - 10.1016/j.jdiacomp.2011.12.001 [doi]
AB  - CONTEXT: Evidence suggests that numerous comorbid conditions contribute to 
      erectile dysfunction (ED) among patients with type 2 diabetes mellitus (T2DM). 
      OBJECTIVE: To review the relationship and mechanism between diabetes, metabolic 
      syndrome, cardiovascular disease (CVD), and ED. METHODS: A manual review of 
      authoritative literature from peer-reviewed publications from January 2001 
      through July 2010 was performed. These publications were further mined to 
      consider the impact of metabolic syndrome as a comorbid condition. Publications 
      from key references were also consulted. RESULTS: The associations between 
      obesity, dyslipidemia, metabolic syndrome, T2DM, CVD, and depression with sexual 
      dysfunction suggest that sexual dysfunction, particularly ED, is a precursor to 
      CVD. Because these conditions share important risk factors with CVD, identifying 
      them and their relationships with the pathogenesis of ED is likely to be critical 
      to the manner in which primary care physicians screen for and manage this 
      condition. CONCLUSIONS: Primary care physicians ought to establish trusting 
      relationships with their patients, providing opportunities for them to probe such 
      sensitive issues as sexual activities, as a means of addressing the possibility 
      of ED. When making the new diagnosis of sexual dysfunction in the absence of 
      metabolic disease or CVD, physicians ought to consider the risk for T2DM and CVD. 
      Associations between metabolic disease, heart disease, and sexual dysfunction 
      further suggest that all patients who are obese and have dyslipidemia, T2DM, 
      and/or depression should be further screened for ED.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Ryan, John G
AU  - Ryan JG
AD  - Division of Primary Care/Health Services Research and Development, Department of 
      Family Medicine and Community Health, University of Miami Miller School of 
      Medicine, Miami, FL, USA. JGRyan@med.miami.edu
FAU - Gajraj, Jason
AU  - Gajraj J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120320
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Phosphodiesterase 5 Inhibitors)
SB  - IM
MH  - Atherosclerosis/complications/epidemiology/psychology
MH  - Depression/epidemiology/psychology
MH  - Diabetes Complications/*complications/epidemiology/psychology
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology/psychology
MH  - Dyslipidemias/complications/epidemiology/psychology
MH  - Erectile Dysfunction/drug therapy/epidemiology/*etiology/psychology
MH  - Humans
MH  - Hypertension/epidemiology/psychology
MH  - Hypogonadism/epidemiology/etiology/psychology
MH  - Incidence
MH  - Male
MH  - Metabolic Syndrome/*complications/epidemiology/psychology
MH  - Obesity/complications/epidemiology/psychology
MH  - Phosphodiesterase 5 Inhibitors/therapeutic use
MH  - Prevalence
MH  - Risk Factors
MH  - Smoking/epidemiology/psychology
MH  - Weight Loss
EDAT- 2012/03/23 06:00
MHDA- 2012/09/07 06:00
CRDT- 2012/03/23 06:00
PHST- 2011/02/08 00:00 [received]
PHST- 2011/12/14 00:00 [revised]
PHST- 2011/12/15 00:00 [accepted]
PHST- 2012/03/23 06:00 [entrez]
PHST- 2012/03/23 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
AID - S1056-8727(11)00160-7 [pii]
AID - 10.1016/j.jdiacomp.2011.12.001 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2012 Mar-Apr;26(2):141-7. doi: 
      10.1016/j.jdiacomp.2011.12.001. Epub 2012 Mar 20.