PMID- 22439294
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20170214
IS  - 0091-2174 (Print)
IS  - 0091-2174 (Linking)
VI  - 42
IP  - 3
DP  - 2011
TI  - Brain-derived neurotrophic factor, adiponectin, and proinflammatory markers in 
      various subtypes of depression in young men.
PG  - 211-26
AB  - OBJECTIVES: We aimed to investigate levels of brain-derived neurotrophic factor 
      (BDNF), adiponectin, and proinflammatory cytokines in various subtypes of 
      depression in a cohort of young men. METHODS: Sixty-two men 18-30 years of age 
      were recruited for the study. Forty-two were newly diagnosed with depression 
      according to DSM-IV criteria and were divided into three subtypes: reactive 
      depression (N = 13), major depression (N = 18), and bipolar depression (N = 10). 
      Controls included 21 young men without significant clinical morbidity. Serum 
      levels of BDNF, adiponectin, high sensitivity C-reactive protein (hsCRP), tumor 
      necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were measured. 
      RESULTS: Serum BDNF was significantly lower and TNF-alpha significantly higher 
      than controls for all subtypes of depression. No statistically significant 
      differences between subtypes were found for BDNF, adiponectin, hsCRP, TNF-alpha, 
      or IL-6. Although established diagnosis of depression and level of TNF-alpha were 
      found to independently affect BDNF level in depressed subjects, they executed 
      inverse effects. No associations were found between BDNF and adiponectin, hsCRP, 
      TNF-alpha, or IL-6 in any depressed subject, showing that decreased BDNF in 
      depression is influenced by multiple factors and complex mechanisms, including 
      environmental and genetic concerns. No influence of age on BDNF level was found 
      in any depressive subtype. CONCLUSIONS: Our results lend support to the cytokine 
      and neurotrophic hypotheses of depression by demonstrating significantly lower 
      levels of BDNF in all subtypes of depression. The mechanism underlying this 
      phenomenon is uncertain and assumed to be multifactorial. Development of novel 
      antidepressant treatments will require a multidisciplinary approach.
FAU - Su, Sheng-Chiang
AU  - Su SC
AD  - Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, 
      ROC.
FAU - Sun, Ming-Tsung
AU  - Sun MT
FAU - Wen, Min-Jie
AU  - Wen MJ
FAU - Lin, Chin-Jung
AU  - Lin CJ
FAU - Chen, Yi-Chyan
AU  - Chen YC
FAU - Hung, Yi-Jen
AU  - Hung YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Psychiatry Med
JT  - International journal of psychiatry in medicine
JID - 0365646
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Bipolar Disorder/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - C-Reactive Protein/*metabolism
MH  - Depressive Disorder/*blood
MH  - Humans
MH  - Inflammation/blood
MH  - Interleukin-6/*blood
MH  - Male
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2011/01/01 00:00
MHDA- 2012/07/20 06:00
CRDT- 2012/03/24 06:00
PHST- 2012/03/24 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 10.2190/PM.42.3.a [doi]
PST - ppublish
SO  - Int J Psychiatry Med. 2011;42(3):211-26. doi: 10.2190/PM.42.3.a.