PMID- 22439901
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20240321
IS  - 1476-9255 (Electronic)
IS  - 1476-9255 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Mar 23
TI  - Effects of Corni fructus on ovalbumin-induced airway inflammation and airway 
      hyper-responsiveness in a mouse model of allergic asthma.
PG  - 9
LID - 10.1186/1476-9255-9-9 [doi]
AB  - BACKGROUND: Allergic asthma is a chronic inflammatory lung disease that is 
      characterized by airway hyperresponsiveness (AHR) to allergens, airway oedema, 
      increased mucus secretion, excess production of T helper-2 (Th2) cytokines, and 
      eosinophil accumulation in the lungs. Corni fructus (CF) is a fruit of Cornus 
      officinalis Sieb. Et. Zucc. (Cornaceae) and has been used in traditional Korean 
      medicine as an anti-inflammatory, analgesic, and diuretic agent. To investigate 
      the anti-asthmatic effects of CF and their underlying mechanism, we examined the 
      influence of CF on the development of pulmonary eosinophilic inflammation and 
      airway hyperresponsiveness in a mouse model of allergic asthma. METHODS: In this 
      study, BALB/c mice were systemically sensitized to ovalbumin (OVA) by 
      intraperitoneal (i.p.), intratracheal (i.t.) injections and intranasal (i.n.) 
      inhalation of OVA. We investigated the effect of CF on airway 
      hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell 
      phenotypes, Th2 cytokine production, and OVA-specific immunoglobulin E (IgE) 
      production. RESULTS: The CF-treated groups showed suppressed eosinophil 
      infiltration, allergic airway inflammation, and AHR via reduced production of 
      interleuin (IL) -5, IL-13, and OVA-specific IgE. CONCLUSIONS: Our data suggest 
      that the therapeutic effects of CF in asthma are mediated by reduced production 
      of Th2 cytokines (IL-5), eotaxin, and OVA-specific IgE and reduced eosinophil 
      infiltration.
FAU - Kim, Seung-Hyung
AU  - Kim SH
AD  - Institute of Traditional Medicine & Bioscience, Daejeon University, Daejeon 
      300-716, Republic of Korea.
FAU - Kim, Bok-Kyu
AU  - Kim BK
AD  - Institute of Traditional Medicine & Bioscience, Daejeon University, Daejeon 
      300-716, Republic of Korea.
FAU - Lee, Young-Cheol
AU  - Lee YC
AD  - Department of Herbology, College of Oriental Medicine, Sangji University, Wonju 
      220-702, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20120323
PL  - England
TA  - J Inflamm (Lond)
JT  - Journal of inflammation (London, England)
JID - 101232234
PMC - PMC3328291
EDAT- 2012/03/24 06:00
MHDA- 2012/03/24 06:01
PMCR- 2012/03/23
CRDT- 2012/03/24 06:00
PHST- 2011/11/18 00:00 [received]
PHST- 2012/03/23 00:00 [accepted]
PHST- 2012/03/24 06:00 [entrez]
PHST- 2012/03/24 06:00 [pubmed]
PHST- 2012/03/24 06:01 [medline]
PHST- 2012/03/23 00:00 [pmc-release]
AID - 1476-9255-9-9 [pii]
AID - 10.1186/1476-9255-9-9 [doi]
PST - epublish
SO  - J Inflamm (Lond). 2012 Mar 23;9(1):9. doi: 10.1186/1476-9255-9-9.