PMID- 22440005
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20151119
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 17
IP  - 4
DP  - 2012 Jun
TI  - Endogenous granulocyte colony-stimulating factor: a biomarker in acute ischemic 
      stroke.
PG  - 319-24
LID - 10.3109/1354750X.2012.668712 [doi]
AB  - Granulocyte colony-stimulating factor (G-CSF) may protect ischemic brain injury 
      either in animal or human. No studies have reported that endogenous G-CSF 
      (enG-CSF) level is related to the severity of ischemic stroke. This study was 
      designed to assess the severity of ischemic patients correlated with the 
      alteration of enG-CSF on the 1st day after an ischemic event. Patient's plasma 
      enG-CSF and scoring of National Institute of Health Stroke Scale were measured on 
      the 1st day after ischemic stroke. The acute ischemic stroke could significantly 
      induce enG-GCF secretion as compared with healthy control group (16.77 vs. 22.86 
      mug/L, p = 0.001). Elevated enG-CSF concentration was positively correlated with 
      the severity of stroke patients on day 1 after the event (p = 0.006; Spearman 
      correlation coefficient = 0.268). The enG-CSF is a good biomarker for prediction 
      of severity of acute ischemic stroke.
FAU - Yu, Shih-Chieh
AU  - Yu SC
AD  - Department of Neurology, Kuang-Tien General Hospital, Taichung, Taiwan.
FAU - Kuo, Chen-Ling
AU  - Kuo CL
FAU - Huang, Ching-Shan
AU  - Huang CS
FAU - Chang, Cheng-Shu
AU  - Chang CS
FAU - Wu, Shey-Lin
AU  - Wu SL
FAU - Su, Shih-Li
AU  - Su SL
FAU - Liu, Chin-San
AU  - Liu CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120323
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Biomarkers)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Brain Ischemia/*blood/pathology
MH  - Case-Control Studies
MH  - Female
MH  - Granulocyte Colony-Stimulating Factor/*blood
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
EDAT- 2012/03/24 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/03/24 06:00
PHST- 2012/03/24 06:00 [entrez]
PHST- 2012/03/24 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.3109/1354750X.2012.668712 [doi]
PST - ppublish
SO  - Biomarkers. 2012 Jun;17(4):319-24. doi: 10.3109/1354750X.2012.668712. Epub 2012 
      Mar 23.