PMID- 22440091
OWN - NLM
STAT- MEDLINE
DCOM- 20121002
LR  - 20221207
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 10
DP  - 2012 Mar 22
TI  - Further evidence for the existence of major susceptibility of nasopharyngeal 
      carcinoma in the region near HLA-A locus in Southern Chinese.
PG  - 57
LID - 10.1186/1479-5876-10-57 [doi]
AB  - BACKGROUND: Nasopharyngeal carcinoma (NPC) is a multi-factorial malignancy 
      closely associated with environmental factors, genetic factors and Epstein-Barr 
      virus infection. Human leukocyte antigen (HLA) complex, specially the region near 
      HLA-A locus, was regarded as a major candidate region bearing NPC genetic 
      susceptibility loci in many previous studies including two recent genome-wide 
      association (GWA) studies. To provide further evidence for the NPC susceptibility 
      in the region near HLA-A locus based on other previous studies, we carried out a 
      two-stage hospital-based case control association study including 535 sporadic 
      NPC patients and 525 cancer-free control subjects from Guangdong, a high 
      prevalence area of NPC in China. METHODS: 38 tag SNPs were initially selected by 
      Heploview from the segment around HLA-A locus (from D6S211 to D6S510) and 
      genotyped on GenomeLab SNPstream platform in 206 cases and 180 controls in the 
      stage 1. Subsequently, the stage 1 significant SNPs and 17 additional SNPs were 
      examined on another platform (Sequenom iPlex Assay) in another independent set of 
      study population including 329 cases and 345 controls. RESULTS: Totally eight 
      SNPs from the segment from D6S211 to D6S510 within HLA complex were found to be 
      significantly associated with NPC. Two of the most significant SNPs (rs9260734 
      and rs2517716) located near to HLA-A and HCG9 respectively were in strong LD with 
      some other SNPs of this region reported by two previous GWA studies. Meanwhile, 
      Meanwhile, novel independent susceptibility loci (rs9404952, Pcombined = 6.6 x 
      10-5, OR combined = 1.45) was found to be close to HLA-G. CONCLUSION: Therefore, 
      our present study supports that the segment from D6S211 to D6S510 in HLA complex 
      region might contain NPC susceptibility loci which indeed needs to be fully 
      investigated in the future.
FAU - Zhao, Manli
AU  - Zhao M
AD  - Cancer Research Institute of Southern Medical University, Guangzhou, China. 
      mingli2006_2006@126.com
FAU - Cai, Hongbing
AU  - Cai H
FAU - Li, Xin
AU  - Li X
FAU - Zheng, Hang
AU  - Zheng H
FAU - Yang, Xuexi
AU  - Yang X
FAU - Fang, Weiyi
AU  - Fang W
FAU - Zhang, Longcheng
AU  - Zhang L
FAU - Wei, Ganguan
AU  - Wei G
FAU - Li, Ming
AU  - Li M
FAU - Yao, Kaitai
AU  - Yao K
FAU - Li, Xin
AU  - Li X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120322
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (HLA-A Antigens)
SB  - IM
MH  - Adult
MH  - Asian People/*genetics/statistics & numerical data
MH  - Carcinoma, Squamous Cell/epidemiology/ethnology/*genetics/pathology
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Loci/genetics
MH  - Genetic Predisposition to Disease
MH  - HLA-A Antigens/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Nasopharyngeal Neoplasms/epidemiology/ethnology/*genetics/pathology
MH  - Neoplasm Staging
MH  - Polymorphism, Single Nucleotide/physiology
MH  - Validation Studies as Topic
PMC - PMC3383544
EDAT- 2012/03/24 06:00
MHDA- 2012/10/04 06:00
PMCR- 2012/03/22
CRDT- 2012/03/24 06:00
PHST- 2012/01/25 00:00 [received]
PHST- 2012/03/22 00:00 [accepted]
PHST- 2012/03/24 06:00 [entrez]
PHST- 2012/03/24 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
PHST- 2012/03/22 00:00 [pmc-release]
AID - 1479-5876-10-57 [pii]
AID - 10.1186/1479-5876-10-57 [doi]
PST - epublish
SO  - J Transl Med. 2012 Mar 22;10:57. doi: 10.1186/1479-5876-10-57.