PMID- 22440260
OWN - NLM
STAT- MEDLINE
DCOM- 20120810
LR  - 20120416
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 141
IP  - 1
DP  - 2012 May 7
TI  - Anti-proliferative and apoptosis induction activities of extracts from Thai 
      medicinal plant recipes selected from MANOSROI II database.
PG  - 451-9
LID - 10.1016/j.jep.2012.03.010 [doi]
AB  - ETHONOPHARMACOLOGICAL RELEVANCES: Traditional medicines have long been used by 
      the Thai people. Several medicinal recipes prepared from a mixture of plants are 
      often used by traditional medicinal practitioners for the treatment of many 
      diseases including cancer. The recipes collected from the Thai medicinal text 
      books were recorded in MANOSROI II database. Anticancer recipes were searched and 
      selected by a computer program using the recipe indication keywords including 
      Ma-reng and San which means cancer in Thai, from the database for anticancer 
      activity investigation. AIM OF STUDY: To investigate anti-cancer activities of 
      the Thai medicinal plant recipes selected from the "MANOSROI II" database. 
      MATERIALS AND METHODS: Anti-proliferative and apoptotic activities of extracts 
      from 121 recipes selected from 56,137 recipes in the Thai medicinal plant recipe 
      "MANOSROI II" database were investigated in two cancer cell lines including human 
      mouth epidermal carcinoma (KB) and human colon adenocarcinoma (HT-29) cell lines 
      using sulforhodamine B (SRB) assay and acridine orange (AO) and ethidium bromide 
      (EB) staining technique, respectively. RESULTS AND CONCLUSIONS: In the SRB assay, 
      recipes NE028 and, S003 gave the highest anti-proliferation activity on KB and 
      HT29 with the IC(50) values of 2.48+/-0.24 and 6.92+/-0.49mug/ml, respectively. In the 
      AO/EB staining assay, recipes S016 and NE028 exhibited the highest apoptotic 
      induction in KB and HT-29 cell lines, respectively. This study has demonstrated 
      that the three Thai medicinal plant recipes selected from "MANOSROI II" database 
      (NE028, S003 and S016) gave active anti-cancer activities according to the NCI 
      classification which can be further developed for anti-cancer treatment.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Manosroi, Jiradej
AU  - Manosroi J
AD  - Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand. 
      jiradej.manosroi8@gmail.com
FAU - Sainakham, Mathukorn
AU  - Sainakham M
FAU - Manosroi, Worapaka
AU  - Manosroi W
FAU - Manosroi, Aranya
AU  - Manosroi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120314
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Antineoplastic Agents, Phytogenic/chemistry/classification/*pharmacology
MH  - Apoptosis/*drug effects
MH  - Cell Proliferation/*drug effects
MH  - Data Mining
MH  - *Databases, Factual
MH  - Dose-Response Relationship, Drug
MH  - *Ethnopharmacology
MH  - HT29 Cells
MH  - Humans
MH  - Inhibitory Concentration 50
MH  - Phytotherapy
MH  - Plant Extracts/chemistry/classification/*pharmacology
MH  - Plants, Medicinal
MH  - Thailand
EDAT- 2012/03/24 06:00
MHDA- 2012/08/11 06:00
CRDT- 2012/03/24 06:00
PHST- 2011/12/08 00:00 [received]
PHST- 2012/02/20 00:00 [revised]
PHST- 2012/03/05 00:00 [accepted]
PHST- 2012/03/24 06:00 [entrez]
PHST- 2012/03/24 06:00 [pubmed]
PHST- 2012/08/11 06:00 [medline]
AID - S0378-8741(12)00158-4 [pii]
AID - 10.1016/j.jep.2012.03.010 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2012 May 7;141(1):451-9. doi: 10.1016/j.jep.2012.03.010. Epub 
      2012 Mar 14.