PMID- 22441212
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20151119
IS  - 1423-002X (Electronic)
IS  - 0378-7346 (Linking)
VI  - 73
IP  - 3
DP  - 2012
TI  - Expression levels of vascular cell adhesion molecule-1 in young and nonobese 
      women with polycystic ovary syndrome.
PG  - 236-41
LID - 10.1159/000334175 [doi]
AB  - BACKGROUND/AIMS: The objective of this study was to measure levels of mRNAs for 
      inflammatory markers and resistin in human peripheral blood mononuclear cells 
      (PBMCs) in young and nonobese women with polycystic ovary syndrome (PCOS). 
      METHODS: Fifteen young, nonobese women with PCOS and 10 age-matched controls were 
      enrolled in this study. Levels of mRNAs for resistin and the inflammatory markers 
      interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant 
      protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1) and vascular cell 
      adhesion molecule-1 (VCAM-1) in human PBMCs were measured using real-time PCR. 
      RESULTS: The mean age and BMI of the women with PCOS were 27.54 +/- 6.3 years and 
      27.4 +/- 5.7, respectively. The women with PCOS had significantly higher fasting 
      and 2-hour insulin levels, homeostasis model assessment of insulin resistance 
      index (HOMA(IR)) and total cholesterol levels than the controls. VCAM-1 and 
      ICAM-1 mRNA levels were significantly higher in women with PCOS than in controls, 
      whereas no differences in resistin, IL-6, TNF-alpha and MCP-1 mRNA levels were 
      observed between the groups. After adjusting for the BMI, only VCAM-1 mRNA levels 
      were significantly higher in women with PCOS than in controls and correlated with 
      the HOMA(IR) and total cholesterol. CONCLUSION: Elevated VCAM-1 in human PBMCs in 
      young, nonobese women with PCOS is associated with insulin resistance, 
      independent of the BMI.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Seow, Kok-Min
AU  - Seow KM
AD  - Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, 
      No. 95 Wen-Chang Road, Taipei, Taiwan.
FAU - Juan, Chi-Chang
AU  - Juan CC
FAU - Wang, Peng-Hui
AU  - Wang PH
FAU - Ho, Low-Tone
AU  - Ho LT
FAU - Hwang, Jiann-Loung
AU  - Hwang JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120321
PL  - Switzerland
TA  - Gynecol Obstet Invest
JT  - Gynecologic and obstetric investigation
JID - 7900587
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Insulin)
RN  - 0 (RNA, Messenger)
RN  - 0 (Resistin)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Biomarkers/metabolism
MH  - *Body Mass Index
MH  - Case-Control Studies
MH  - Cholesterol/blood
MH  - Cytokines/metabolism
MH  - Female
MH  - Humans
MH  - Inflammation/metabolism
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Leukocytes, Mononuclear/metabolism
MH  - Obesity/metabolism
MH  - Polycystic Ovary Syndrome/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Real-Time Polymerase Chain Reaction
MH  - Resistin/metabolism
MH  - Vascular Cell Adhesion Molecule-1/*metabolism
MH  - Young Adult
EDAT- 2012/03/24 06:00
MHDA- 2012/08/22 06:00
CRDT- 2012/03/24 06:00
PHST- 2011/03/02 00:00 [received]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2012/03/24 06:00 [entrez]
PHST- 2012/03/24 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - 000334175 [pii]
AID - 10.1159/000334175 [doi]
PST - ppublish
SO  - Gynecol Obstet Invest. 2012;73(3):236-41. doi: 10.1159/000334175. Epub 2012 Mar 
      21.