PMID- 22441653
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20120424
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 54
IP  - 10
DP  - 2012 May
TI  - Immune responses driven by protective human leukocyte antigen alleles from 
      long-term nonprogressors are associated with low HIV reservoir in central memory 
      CD4 T cells.
PG  - 1495-503
LID - 10.1093/cid/cis188 [doi]
AB  - BACKGROUND: The stable immune control of human immunodeficiency virus (HIV) in 
      long-term nonprogressors (LTNPs) with protective human leukocyte antigen (HLA) 
      alleles raises the question of whether and how these alleles influence the immune 
      distribution of the HIV reservoirs. METHODS: Cell-associated HIV-DNA levels were 
      quantified in blood sorted resting CD4 T-cell subsets from 8 LTNPs with and 10 
      without HLA-B*27 or HLA-B*57 alleles (HLA-B27/B57). RESULTS: A remarkably lower 
      infection level of central memory CD4 T cells (T(CM)) was an exclusive feature 
      that distinguished the HLA-B27/B57 HIV reservoirs from the other ones. In LTNPs, 
      T(CM) protection was correlated with preservation of T(CM) counts, which 
      correlated positively with the magnitude of HIV Gag-specific CD8 T cells. In 
      HLA-B27/B57 LTNPs, a lower activation level of their memory CD4 T cells was 
      associated with lower amounts of cell HIV-DNA in each resting memory CD4 subset 
      and were also associated with higher ratios of HIV Gag-specific CD8 T cells per 
      infected resting CD4 T cell (effector/target [E/T]). As a result, HLA-B27/B57 E/T 
      ratios were negatively correlated with the contribution of memory CD4 T-cell 
      subsets to the total HIV reservoirs. CONCLUSIONS: The potent antiviral immunity 
      governed by the protective HLA-B27/B57 alleles, by limiting T(CM) infection and 
      pool exhaustion, are associated with a reduced T(CM) contribution to the HIV 
      reservoir.
FAU - Descours, Benjamin
AU  - Descours B
AD  - Immunity and Infection Laboratory, Pierre and Marie Curie University, INSERM UMRS 
      945, Pitie-Salpetriere Hospital, Paris, France.
FAU - Avettand-Fenoel, Veronique
AU  - Avettand-Fenoel V
FAU - Blanc, Catherine
AU  - Blanc C
FAU - Samri, Assia
AU  - Samri A
FAU - Melard, Adeline
AU  - Melard A
FAU - Supervie, Virginie
AU  - Supervie V
FAU - Theodorou, Ioannis
AU  - Theodorou I
FAU - Carcelain, Guislaine
AU  - Carcelain G
FAU - Rouzioux, Christine
AU  - Rouzioux C
FAU - Autran, Brigitte
AU  - Autran B
CN  - ALT ANRS CO15 Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120322
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (DNA, Viral)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - DNA, Viral/isolation & purification
MH  - HIV Infections/*immunology/*virology
MH  - *HIV Long-Term Survivors
MH  - HLA-B Antigens/*genetics/immunology
MH  - Humans
MH  - Proviruses/isolation & purification
MH  - Viral Load
FIR - Agut, Henri
IR  - Agut H
FIR - Clauvel, Jean-Pierre
IR  - Clauvel JP
FIR - Costagliola, Dominique
IR  - Costagliola D
FIR - DaSilva, Maciel-Bosco
IR  - DaSilva MB
FIR - Debre, Patrice
IR  - Debre P
FIR - Sicard, Didier
IR  - Sicard D
FIR - Viard, Jean-Paul
IR  - Viard JP
EDAT- 2012/03/24 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/03/24 06:00
PHST- 2012/03/24 06:00 [entrez]
PHST- 2012/03/24 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - cis188 [pii]
AID - 10.1093/cid/cis188 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2012 May;54(10):1495-503. doi: 10.1093/cid/cis188. Epub 2012 Mar 
      22.