PMID- 22441965
OWN - NLM
STAT- MEDLINE
DCOM- 20140130
LR  - 20211021
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 33
IP  - 7
DP  - 2013 Jul
TI  - Increased levels of matrix metalloproteinase-3 in the sera and synovial fluids of 
      patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis: 
      report of 2 cases.
PG  - 1911-3
LID - 10.1007/s00296-012-2405-5 [doi]
AB  - Pustulotic arthro-osteitis (PAO) is occasionally seen in patients with 
      palmoplantar pustulosis (PPP); however, its pathogenesis is still obscure. 
      Herein, two patients with PAO associated with PPP were described. Both patients 
      developed hydrarthrosis on the knees, along with sternocostoclavicular pain. 
      Detail examination revealed odontogenic infection in both cases. Matrix 
      metalloproteinase-3 (MMP-3) is a useful marker reflecting the activity of 
      rheumatoid arthritis. In this study, MMP-3 levels in the sera as well as joint 
      fluids were examined. Serum MMP-3 levels were increased in both cases (274 ng/ml 
      in Case 1 and 242 ng/ml in Case 2, normal; 17.3-59.7). Also, MMP-3 concentration 
      in the joint fluids was markedly elevated (Case 1 > 80,000 ng/ml and 48,000 ng/ml 
      in Case 2). Our studies suggest that MMP-3 may play a role in the pathogenesis of 
      joint involvement of PPP.
FAU - Yamamoto, Toshiyuki
AU  - Yamamoto T
LA  - eng
PT  - Case Reports
PT  - Letter
DEP - 20120324
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Dental Caries/complications
MH  - Female
MH  - Humans
MH  - Knee Joint/*enzymology
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Osteitis/blood/diagnosis/*enzymology/etiology
MH  - Periapical Abscess/complications
MH  - Psoriasis/blood/diagnosis/*enzymology/etiology
MH  - Synovial Fluid/*enzymology
MH  - Up-Regulation
EDAT- 2012/03/24 06:00
MHDA- 2014/01/31 06:00
CRDT- 2012/03/24 06:00
PHST- 2011/11/08 00:00 [received]
PHST- 2012/03/11 00:00 [accepted]
PHST- 2012/03/24 06:00 [entrez]
PHST- 2012/03/24 06:00 [pubmed]
PHST- 2014/01/31 06:00 [medline]
AID - 10.1007/s00296-012-2405-5 [doi]
PST - ppublish
SO  - Rheumatol Int. 2013 Jul;33(7):1911-3. doi: 10.1007/s00296-012-2405-5. Epub 2012 
      Mar 24.