PMID- 22442750
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20240321
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Linking)
VI  - 3
IP  - 3
DP  - 2012 Mar 15
TI  - ApoE isoforms, treatment of diabetes and the risk of coronary heart disease.
PG  - 54-9
LID - 10.4239/wjd.v3.i3.54 [doi]
AB  - AIM: To analyze the risk of coronary heart disease in patients with type 2 
      diabetes mellitus (T2DM) receiving standard medical treatment. METHODS: We 
      performed a retrospective chart analysis of 269 middle-aged patients (age 45-64 
      years, mean age, 53.9 +/- 5.5 years) with T2DM and without atherosclerotic 
      cardiovascular events who underwent typing to determine their apolipoprotein E 
      (apoE) isoforms. The apoE isoforms were determined using isoelectric focusing, 
      followed by immunoblotting. We retrospectively evaluated the charts of the 269 
      patients, recorded between their first visit to the hospital (the study's start 
      point, between 1987 and 1992) and the occurrence of an atherosclerotic 
      cardiovascular event (the study's endpoint) or January 2004, whichever came 
      first. The age-adjusted mean values and the prevalences of covariates were 
      calculated to compare the laboratory data among the apoE phenotypes. To 
      investigate the association of risk factors with the incidence of coronary heart 
      disease during the follow-up period, monovariate and multivariate Cox regression 
      models were used. RESULTS: At enrollment, the mean serum low density lipoprotein 
      (LDL) cholesterol levels were lowest (2.92 +/- 0.89 mmol/L) among the subjects with 
      apoE2 (apoE2/2 or apoE2/3) and highest (3.52 +/- 0.77 mmol/L) among the subjects 
      with apoE4 (apoE3/4 or apoE4/4). No significant differences in mean age or the 
      percentage of smokers were observed among the three groups. Furthermore, no 
      significant differences were observed in the systolic and diastolic blood 
      pressures, body mass index, HbA1c level or serum triglyceride levels among the 
      three groups. There were 47 cases of coronary heart disease over 3285 
      person-years of follow-up. An age-adjusted multivariate Cox proportional model 
      identified diabetic retinopathy (hazard ratio, 2.38, 95% CI: 1.28-4.43, P = 
      0.006), a high systolic blood pressure (hazard ratio, 1.04, 95% CI: 1.02-1.06, P 
      < 0.001) and high HbA1c values (hazard ratio, 1.19, 95% CI: 1.02-1.38, P = 
      0.0029), but not the LDL cholesterol value at enrollment (hazard ratio, 1.01, 95% 
      CI: 0.97-1.05, P = 0.77) nor the specific apoE isoform, as significant predictors 
      of coronary heart disease. CONCLUSION: Under standard medical treatment of 
      diabetes, including the control of LDL cholesterol levels, the apoE4 isoform was 
      not associated with coronary heart disease among T2DM patients.
FAU - Ehara, Hideki
AU  - Ehara H
AD  - Hideki Ehara, Hiroji Kitazato, Shoji Kawazu, Yasuo Akanuma, the Institute for 
      Adult Diseases, Asahi Life Foundation, 2-2-6, Nihonbashi-bakurocho, Chuo-ku, 
      Tokyo 103-0002, Japan.
FAU - Yamamoto-Honda, Ritsuko
AU  - Yamamoto-Honda R
FAU - Kitazato, Hiroji
AU  - Kitazato H
FAU - Takahashi, Yoshihiko
AU  - Takahashi Y
FAU - Kawazu, Shoji
AU  - Kawazu S
FAU - Akanuma, Yasuo
AU  - Akanuma Y
FAU - Noda, Mitsuhiko
AU  - Noda M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC3310005
OTO - NOTNLM
OT  - Apolipoprotein E isoform
OT  - Atherosclerosis
OT  - Type 2 diabetes
EDAT- 2012/03/24 06:00
MHDA- 2012/03/24 06:01
PMCR- 2012/03/15
CRDT- 2012/03/24 06:00
PHST- 2011/10/10 00:00 [received]
PHST- 2012/03/02 00:00 [revised]
PHST- 2012/03/09 00:00 [accepted]
PHST- 2012/03/24 06:00 [entrez]
PHST- 2012/03/24 06:00 [pubmed]
PHST- 2012/03/24 06:01 [medline]
PHST- 2012/03/15 00:00 [pmc-release]
AID - 10.4239/wjd.v3.i3.54 [doi]
PST - ppublish
SO  - World J Diabetes. 2012 Mar 15;3(3):54-9. doi: 10.4239/wjd.v3.i3.54.