PMID- 22444546
OWN - NLM
STAT- MEDLINE
DCOM- 20120808
LR  - 20151119
IS  - 1995-9133 (Electronic)
IS  - 1684-1182 (Linking)
VI  - 45
IP  - 2
DP  - 2012 Apr
TI  - Patterns of sensitization to peanut allergen components in Taiwanese Preschool 
      children.
PG  - 90-5
LID - 10.1016/j.jmii.2011.11.001 [doi]
AB  - BACKGROUND/PURPOSE: Peanut allergy is very common in Western countries, although 
      it is seldom encountered in Eastern countries. Peanuts are comprised of at least 
      11 components, but the contribution to clinical symptoms by each component in 
      each individual is not known. This study investigated the distributions of 
      sensitivity to peanut allergen components among Taiwanese children who were 
      sensitized to peanuts and followed the evolution of sensitization patterns to 
      these components. METHODS: We enrolled 29 preschool children (age=2.11+/-1.36 
      years) who were sensitized to peanuts above class 3. Serum was analyzed for 
      specific immunoglobulin E (IgE) antibodies to recombinant Ara h 1, Ara h 2, Ara h 
      3, Ara h 8, and Ara h 9. Allergen component-specific IgE >/=0.35 kU(A)/L was 
      defined as positive. Eighteen children were retested 22.64+/-5.1 months later. 
      Peanut allergy symptoms were recorded from detailed questionnaires. RESULTS: The 
      percentages of children sensitized to Ara h 1, 2, 3, 8, and 9 were, respectively, 
      51.8%, 65.5%, 62.1%, 13.8%, and 24.1%. Regarding changing patterns of peanut 
      component sensitization at follow-up, children with clinical symptoms to peanuts 
      had persistent elevations of Ara h 2-specific IgE: 12.6+/-1.01 up to 34.15+/-19.4 
      kU(A)/L; p=0.144. In contrast, Ara h 2 concentrations decreased significantly in 
      children without clinical symptoms. Ara h 8 and 9 were nonspecific for children 
      with or without symptoms. CONCLUSION: Ara h 1, Ara h 2, and Ara h 3 were major 
      components contributing to peanut sensitization in Taiwanese children. Ara h 2 
      was probably the most important component that contributed to clinical symptoms 
      and remained steady in children who had peanut allergy.
CI  - Copyright (c) 2011. Published by Elsevier B.V.
FAU - Lin, Yang-Te
AU  - Lin YT
AD  - Division of Allergy Asthma and Rheumatology, Department of Pediatrics, Chang Gung 
      Memorial Hospital, Taoyuan, Taiwan.
FAU - Wu, Chih-Te Charles
AU  - Wu CT
FAU - Cheng, Ju-Hui
AU  - Cheng JH
FAU - Huang, Jing-Long
AU  - Huang JL
FAU - Yeh, Kuo-Wei
AU  - Yeh KW
LA  - eng
PT  - Journal Article
DEP - 20120321
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 0 (Allergens)
RN  - 0 (Antibodies)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*analysis/*immunology
MH  - Antibodies/blood
MH  - Arachis/*chemistry/*immunology
MH  - Child, Preschool
MH  - Female
MH  - Food Hypersensitivity/*epidemiology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Taiwan/epidemiology
EDAT- 2012/03/27 06:00
MHDA- 2012/08/09 06:00
CRDT- 2012/03/27 06:00
PHST- 2011/07/08 00:00 [received]
PHST- 2011/07/13 00:00 [revised]
PHST- 2011/09/13 00:00 [accepted]
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/08/09 06:00 [medline]
AID - S1684-1182(11)00202-7 [pii]
AID - 10.1016/j.jmii.2011.11.001 [doi]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2012 Apr;45(2):90-5. doi: 10.1016/j.jmii.2011.11.001. 
      Epub 2012 Mar 21.