PMID- 22445461
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20160526
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 137
IP  - 1-3
DP  - 2012 May
TI  - Niacin subsensitivity is associated with functional impairment in schizophrenia.
PG  - 180-4
LID - 10.1016/j.schres.2012.03.001 [doi]
AB  - OBJECTIVE: Sensitivity to the skin flush effect of niacin is reduced in a portion 
      of patients with schizophrenia. Though this peripheral physiological abnormality 
      has been widely replicated, its relevance to neuropsychiatric manifestations of 
      the illness has been unclear. The goal of this study was to determine if the 
      niacin response abnormality in schizophrenia is associated with functional 
      impairment. METHODS: Following psychiatric assessment, a Global Assessment of 
      Functioning (GAF) score was assigned to each of 40 volunteers with schizophrenia. 
      For each subject, the blood flow responses to several concentrations of topical 
      methylnicotinate were recorded. Blood flow was measured objectively, using laser 
      Doppler flowmetry. From the dose-response data, EC(50) values were derived. GAF 
      scores were assigned without knowledge of the participants' niacin response data. 
      RESULTS: There was a significant negative correlation between GAF scores and 
      EC(50) values for methylnicotinate (Pearson r=-0.42; p=0.007). CONCLUSIONS: 
      Reduced niacin sensitivity is associated with greater functional impairment among 
      patients with schizophrenia. These findings raise the possibility that a subset 
      of schizophrenia patients possesses a biochemical abnormality that reduces niacin 
      sensitivity in the skin and contributes to functional impairment from the 
      disease.
CI  - Published by Elsevier B.V.
FAU - Messamore, Erik
AU  - Messamore E
AD  - Behavioral Health and Clinical Neurosciences Division, Portland VA Medical 
      Center, Portland, OR 97239, USA. Erik.Messamore@va.gov
LA  - eng
GR  - R03 MH070434/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120322
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 2679MF687A (Niacin)
SB  - IM
MH  - Administration, Cutaneous
MH  - Adult
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Flushing/chemically induced/metabolism
MH  - Humans
MH  - Laser-Doppler Flowmetry
MH  - Male
MH  - Middle Aged
MH  - *Niacin/administration & dosage
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*diagnosis/*physiopathology
MH  - Skin/blood supply/*drug effects
MH  - Statistics as Topic
EDAT- 2012/03/27 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/03/27 06:00
PHST- 2011/04/12 00:00 [received]
PHST- 2012/02/29 00:00 [revised]
PHST- 2012/03/02 00:00 [accepted]
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - S0920-9964(12)00154-5 [pii]
AID - 10.1016/j.schres.2012.03.001 [doi]
PST - ppublish
SO  - Schizophr Res. 2012 May;137(1-3):180-4. doi: 10.1016/j.schres.2012.03.001. Epub 
      2012 Mar 22.