PMID- 22445462
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20160526
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 137
IP  - 1-3
DP  - 2012 May
TI  - Cognitive impairment is related to oxidative stress and chemokine levels in first 
      psychotic episodes.
PG  - 66-72
LID - 10.1016/j.schres.2012.03.004 [doi]
AB  - INTRODUCTION: This study measures the levels of various markers of oxidative 
      stress and inflammation in blood samples from first-episode psychosis (FEP) 
      patients, and examines the association between these peripheral biomarkers and 
      cognitive performance at 6 months after treatment. METHODS: Twenty-eight FEP 
      patients and 28 healthy controls (matched by age, sex and educational level) had 
      blood samples taken at admission for assessment of total antioxidant status, 
      superoxide dismutase (SOD), total glutathione (GSH), catalase (CAT), glutathione 
      peroxidase, lipid peroxidation, nitrites and the chemokine monocyte 
      chemoattractant protein-1 (MCP-1). A battery of cognitive tests was also applied 
      to the healthy controls and those FEP patients who were in remission at 6 months 
      after the acute episode. RESULTS: FEP patients had significantly lower levels of 
      total antioxidant status, catalase and glutathione peroxidase, compared with the 
      healthy controls. Regression analyses found that MCP-1 levels were negatively 
      associated with learning and memory (verbal and working), nitrite levels were 
      negatively associated with executive function, and glutathione levels were 
      positively associated with executive function. CONCLUSION: Our results suggest an 
      association between certain peripheral markers of oxidative stress and 
      inflammation and specific aspects of cognitive functioning in FEP patients. 
      Further studies on the association between MCP-1 and cognition are warranted.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Martinez-Cengotitabengoa, Monica
AU  - Martinez-Cengotitabengoa M
AD  - CIBERSAM, Centro de Investigacion Biomedica en Red de Salud Mental, Spain. 
      monica.martinezcengotitabengoa@osakidetza.net
FAU - Mac-Dowell, Karina Soledad
AU  - Mac-Dowell KS
FAU - Leza, Juan Carlos
AU  - Leza JC
FAU - Mico, Juan Antonio
AU  - Mico JA
FAU - Fernandez, Miryam
AU  - Fernandez M
FAU - Echevarria, Enrique
AU  - Echevarria E
FAU - Sanjuan, Julio
AU  - Sanjuan J
FAU - Elorza, Julian
AU  - Elorza J
FAU - Gonzalez-Pinto, Ana
AU  - Gonzalez-Pinto A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120322
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Nitrites)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Catalase/blood
MH  - Chemokine CCL2/*blood
MH  - Cognition Disorders/*etiology
MH  - Female
MH  - Glutathione/blood
MH  - Glutathione Peroxidase/blood
MH  - Humans
MH  - Linear Models
MH  - Lipid Peroxidation/physiology
MH  - Male
MH  - Neuropsychological Tests
MH  - Nitrites/blood
MH  - Oxidative Stress/physiology
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*blood/*complications
MH  - Statistics, Nonparametric
MH  - Superoxide Dismutase/blood
MH  - Young Adult
EDAT- 2012/03/27 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/03/27 06:00
PHST- 2011/06/22 00:00 [received]
PHST- 2012/02/14 00:00 [revised]
PHST- 2012/03/01 00:00 [accepted]
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - S0920-9964(12)00157-0 [pii]
AID - 10.1016/j.schres.2012.03.004 [doi]
PST - ppublish
SO  - Schizophr Res. 2012 May;137(1-3):66-72. doi: 10.1016/j.schres.2012.03.004. Epub 
      2012 Mar 22.