PMID- 22445478
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20221207
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 77
IP  - 4
DP  - 2012 Apr
TI  - Diabetic nephropathy among Mexican Americans.
PG  - 332-44
AB  - The incidence of diabetic nephropathy (DN) is growing rapidly worldwide as a 
      consequence of the rising prevalence of Type 2 diabetes mellitus (T2DM). Among 
      U.S. ethnic groups, Mexican Americans have a disproportionately high incidence 
      and prevalence of DN and associated end-stage renal disease (ESRD). In 
      communities bordering Mexico, as many as 90% of Mexican American patients with 
      ESRD also suffer from T2DM compared to only 50% of non-Hispanic Whites (NHW). 
      Both socio-economic factors and genetic predisposition appear to have a strong 
      influence on this association. In addition, certain pathogenetic and clinical 
      features of T2DM and DN are different in Mexican Americans compared to NHW, 
      raising questions as to whether the diagnostic and treatment strategies that are 
      standard practice in the NHW patient population may not be applicable in Mexican 
      Americans. This article reviews the epidemiology of DN in Mexican Americans, 
      describes the pathophysiology and associated risk factors, and identifies gaps in 
      our knowledge and understanding that needs to be addressed by future 
      investigations.
FAU - Debnath, Subrata
AU  - Debnath S
AD  - Division of Nephrology, University of Texas Health Science Center, San Antonio, 
      TX, USA.
FAU - Thameem, Farook
AU  - Thameem F
FAU - Alves, Tahira
AU  - Alves T
FAU - Nolen, Jacqueline
AU  - Nolen J
FAU - Al-Shahrouri, Hania
AU  - Al-Shahrouri H
FAU - Bansal, Shweta
AU  - Bansal S
FAU - Abboud, Hanna E
AU  - Abboud HE
FAU - Fanti, Paolo
AU  - Fanti P
LA  - eng
GR  - R01 DK078971/DK/NIDDK NIH HHS/United States
GR  - DK-R01-078971/DK/NIDDK NIH HHS/United States
GR  - AT004490/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
SB  - IM
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/complications/*epidemiology
MH  - Diabetic Nephropathies/complications/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Kidney Failure, Chronic/complications/*epidemiology
MH  - Mexican Americans/*statistics & numerical data
MH  - Obesity/complications/*epidemiology
MH  - Poverty
MH  - Prevalence
MH  - Risk Factors
MH  - Texas/epidemiology
MH  - White People/statistics & numerical data
PMC - PMC4407344
EDAT- 2012/03/27 06:00
MHDA- 2012/06/13 06:00
PMCR- 2012/04/01
CRDT- 2012/03/27 06:00
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - 9441 [pii]
AID - 10.5414/cn107487 [doi]
PST - ppublish
SO  - Clin Nephrol. 2012 Apr;77(4):332-44. doi: 10.5414/cn107487.