PMID- 22445704
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20211021
IS  - 0165-1781 (Print)
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 196
IP  - 2-3
DP  - 2012 Apr 30
TI  - Negative symptoms in individuals at clinical high risk of psychosis.
PG  - 220-4
LID - 10.1016/j.psychres.2012.02.018 [doi]
AB  - Negative symptoms are present in the psychosis prodrome. However, the extent to 
      which these symptoms are present prior to the onset of the first episode of 
      psychosis remains under-researched. The goal of this study is to examine negative 
      symptoms in a sample of individuals at clinical high risk (CHR) for psychosis and 
      to determine if they are predictive of conversion to psychosis. Participants 
      (n=138) were all participants in the North American Prodrome Longitudinal Study 
      (NAPLS 1) project. Negative symptoms were assessed longitudinally using the Scale 
      of Prodromal Symptoms. The mean total negative symptom score at baseline was 
      11.0, with 82.0% of the sample scoring at moderate severity or above on at least 
      one negative symptom. Over the course of 12 months, the symptoms remained in the 
      above moderate severity range for 54.0% of participants. Associations between 
      individual symptoms were moderate, and a factor analysis confirmed that all 
      negative symptoms loaded heavily on one factor. Negative symptoms were more 
      severe and persistent overtime in those who converted to psychosis, significantly 
      predicting the likelihood of conversion. Thus, early and persistent negative 
      symptoms may represent a vulnerability for risk of developing psychosis.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Piskulic, Danijela
AU  - Piskulic D
AD  - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. 
      dpiskuli@ucalgary.ca
FAU - Addington, Jean
AU  - Addington J
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
FAU - Cannon, Tyrone D
AU  - Cannon TD
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
FAU - Heinssen, Robert
AU  - Heinssen R
FAU - Perkins, Diana O
AU  - Perkins DO
FAU - Seidman, Larry J
AU  - Seidman LJ
FAU - Tsuang, Ming T
AU  - Tsuang MT
FAU - Walker, Elaine F
AU  - Walker EF
FAU - Woods, Scott W
AU  - Woods SW
FAU - McGlashan, Thomas H
AU  - McGlashan TH
LA  - eng
GR  - R01 MH061523/MH/NIMH NIH HHS/United States
GR  - R18 MH43518/MH/NIMH NIH HHS/United States
GR  - R01 MH066069/MH/NIMH NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - R01MH061523/MH/NIMH NIH HHS/United States
GR  - U01 MH066134/MH/NIMH NIH HHS/United States
GR  - R01MH062066/MH/NIMH NIH HHS/United States
GR  - K05MH01654/MH/NIMH NIH HHS/United States
GR  - R01 MH043518/MH/NIMH NIH HHS/United States
GR  - K05 MH001654/MH/NIMH NIH HHS/United States
GR  - K24 MH76191/MH/NIMH NIH HHS/United States
GR  - R01 MH065079/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - R01 MH60720/MH/NIMH NIH HHS/United States
GR  - K23 MH001905/MH/NIMH NIH HHS/United States
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
GR  - R01 MH062066/MH/NIMH NIH HHS/United States
GR  - R01 MH065562/MH/NIMH NIH HHS/United States
GR  - R21MH075027/MH/NIMH NIH HHS/United States
GR  - R21 MH075027/MH/NIMH NIH HHS/United States
GR  - U01 MH066160/MH/NIMH NIH HHS/United States
GR  - K24 MH076191/MH/NIMH NIH HHS/United States
GR  - R01 MH060720/MH/NIMH NIH HHS/United States
GR  - R37 MH043518/MH/NIMH NIH HHS/United States
GR  - K23 MH01905/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120322
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Disease Progression
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*complications/*diagnosis
MH  - Risk Factors
MH  - Time Factors
PMC - PMC4119605
MID - NIHMS493762
EDAT- 2012/03/27 06:00
MHDA- 2012/07/20 06:00
PMCR- 2014/08/03
CRDT- 2012/03/27 06:00
PHST- 2011/08/03 00:00 [received]
PHST- 2012/02/12 00:00 [revised]
PHST- 2012/02/15 00:00 [accepted]
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
PHST- 2014/08/03 00:00 [pmc-release]
AID - S0165-1781(12)00100-X [pii]
AID - 10.1016/j.psychres.2012.02.018 [doi]
PST - ppublish
SO  - Psychiatry Res. 2012 Apr 30;196(2-3):220-4. doi: 10.1016/j.psychres.2012.02.018. 
      Epub 2012 Mar 22.