PMID- 22445725
OWN - NLM
STAT- MEDLINE
DCOM- 20120921
LR  - 20211021
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 210
DP  - 2012 May 17
TI  - Effects of acute restraint-induced stress on glucocorticoid receptors and 
      brain-derived neurotrophic factor after mild traumatic brain injury.
PG  - 393-402
LID - 10.1016/j.neuroscience.2012.03.005 [doi]
AB  - We have previously reported that experimental mild traumatic brain injury results 
      in increased sensitivity to stressful events during the first post-injury weeks, 
      as determined by analyzing the hypothalamic-pituitary-adrenal (HPA) axis 
      regulation following restraint-induced stress. This is the same time period when 
      rehabilitative exercise has proven to be ineffective after a mild 
      fluid-percussion injury (FPI). Here we evaluated effects of stress on 
      neuroplasticity. Adult male rats underwent either an FPI or sham injury. 
      Additional rats were only exposed to anesthesia. Rats were exposed to 30 min of 
      restraint stress, followed by tail vein blood collection at post-injury days 
      (PID) 1, 7, and 14. The response to dexamethasone (DEX) was also evaluated. 
      Hippocampal tissue was collected 120 min after stress onset. Brain-derived 
      neurotrophic factor (BDNF) along with glucocorticoid (GR) and mineralocorticoid 
      (MR) receptors was determined by Western blot analysis. Results indicated 
      injury-dependent changes in glucocorticoid and mineralocorticoid receptors that 
      were influenced by the presence of dexamethasone. Control and FPI rats responded 
      differentially to DEX in that GR increases after receiving the lower dose of DEX 
      were longer lasting in the FPI group. A suppression of MR was found at PID 1 in 
      vehicle-treated FPI and Sham groups. Decreases in the precursor form of BDNF were 
      observed in different FPI groups at PIDs 7 and 14. These findings suggest that 
      the increased sensitivity to stressful events during the first post-injury weeks, 
      after a mild FPI, has an impact on hippocampal neuroplasticity.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Griesbach, G S
AU  - Griesbach GS
AD  - Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, 
      CA, USA. ggriesbach@mednet.ucla.edu
FAU - Vincelli, J
AU  - Vincelli J
FAU - Tio, D L
AU  - Tio DL
FAU - Hovda, D A
AU  - Hovda DA
LA  - eng
GR  - R01 NS061960/NS/NINDS NIH HHS/United States
GR  - NS6190/NS/NINDS NIH HHS/United States
GR  - R01 NS061960-04/NS/NINDS NIH HHS/United States
GR  - R01 NS061960-02/NS/NINDS NIH HHS/United States
GR  - R01 NS061960-01A2/NS/NINDS NIH HHS/United States
GR  - R01 NS061960-02S1/NS/NINDS NIH HHS/United States
GR  - R01 NS061960-03/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120315
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glucocorticoids)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (Receptors, Mineralocorticoid)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain Injuries/*complications/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Dexamethasone/pharmacology
MH  - Glucocorticoids/pharmacology
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Neuronal Plasticity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Glucocorticoid/*metabolism
MH  - Receptors, Mineralocorticoid/metabolism
MH  - Restraint, Physical
MH  - Stress, Psychological/*complications/*metabolism
PMC - PMC3358418
MID - NIHMS369121
EDAT- 2012/03/27 06:00
MHDA- 2012/09/22 06:00
PMCR- 2013/05/17
CRDT- 2012/03/27 06:00
PHST- 2011/10/31 00:00 [received]
PHST- 2012/02/23 00:00 [revised]
PHST- 2012/03/04 00:00 [accepted]
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/09/22 06:00 [medline]
PHST- 2013/05/17 00:00 [pmc-release]
AID - S0306-4522(12)00217-5 [pii]
AID - 10.1016/j.neuroscience.2012.03.005 [doi]
PST - ppublish
SO  - Neuroscience. 2012 May 17;210:393-402. doi: 10.1016/j.neuroscience.2012.03.005. 
      Epub 2012 Mar 15.