PMID- 22446962
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20221207
IS  - 1546-1718 (Electronic)
IS  - 1061-4036 (Linking)
VI  - 44
IP  - 5
DP  - 2012 Mar 25
TI  - A genome-wide association study identifies three new risk loci for Kawasaki 
      disease.
PG  - 517-21
LID - 10.1038/ng.2220 [doi]
AB  - We performed a genome-wide association study (GWAS) of Kawasaki disease in 
      Japanese subjects using data from 428 individuals with Kawasaki disease (cases) 
      and 3,379 controls genotyped at 473,803 SNPs. We validated the association 
      results in two independent replication panels totaling 754 cases and 947 
      controls. We observed significant associations in the FAM167A-BLK region at 
      8p22-23 (rs2254546, P = 8.2 x 10(-21)), in the human leukocyte antigen (HLA) 
      region at 6p21.3 (rs2857151, P = 4.6 x 10(-11)) and in the CD40 region at 20q13 
      (rs4813003, P = 4.8 x 10(-8)). We also replicated the association of a functional 
      SNP of FCGR2A (rs1801274, P = 1.6 x 10(-6)) identified in a recently reported 
      GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis 
      and pathophysiology of Kawasaki disease.
FAU - Onouchi, Yoshihiro
AU  - Onouchi Y
AD  - Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, 
      Yokohama, Japan. onouchi@src.riken.jp
FAU - Ozaki, Kouichi
AU  - Ozaki K
FAU - Burns, Jane C
AU  - Burns JC
FAU - Shimizu, Chisato
AU  - Shimizu C
FAU - Terai, Masaru
AU  - Terai M
FAU - Hamada, Hiromichi
AU  - Hamada H
FAU - Honda, Takafumi
AU  - Honda T
FAU - Suzuki, Hiroyuki
AU  - Suzuki H
FAU - Suenaga, Tomohiro
AU  - Suenaga T
FAU - Takeuchi, Takashi
AU  - Takeuchi T
FAU - Yoshikawa, Norishige
AU  - Yoshikawa N
FAU - Suzuki, Yoichi
AU  - Suzuki Y
FAU - Yasukawa, Kumi
AU  - Yasukawa K
FAU - Ebata, Ryota
AU  - Ebata R
FAU - Higashi, Kouji
AU  - Higashi K
FAU - Saji, Tsutomu
AU  - Saji T
FAU - Kemmotsu, Yasushi
AU  - Kemmotsu Y
FAU - Takatsuki, Shinichi
AU  - Takatsuki S
FAU - Ouchi, Kazunobu
AU  - Ouchi K
FAU - Kishi, Fumio
AU  - Kishi F
FAU - Yoshikawa, Tetsushi
AU  - Yoshikawa T
FAU - Nagai, Toshiro
AU  - Nagai T
FAU - Hamamoto, Kunihiro
AU  - Hamamoto K
FAU - Sato, Yoshitake
AU  - Sato Y
FAU - Honda, Akihito
AU  - Honda A
FAU - Kobayashi, Hironobu
AU  - Kobayashi H
FAU - Sato, Junichi
AU  - Sato J
FAU - Shibuta, Shoichi
AU  - Shibuta S
FAU - Miyawaki, Masakazu
AU  - Miyawaki M
FAU - Oishi, Ko
AU  - Oishi K
FAU - Yamaga, Hironobu
AU  - Yamaga H
FAU - Aoyagi, Noriyuki
AU  - Aoyagi N
FAU - Iwahashi, Seiji
AU  - Iwahashi S
FAU - Miyashita, Ritsuko
AU  - Miyashita R
FAU - Murata, Yuji
AU  - Murata Y
FAU - Sasago, Kumiko
AU  - Sasago K
FAU - Takahashi, Atsushi
AU  - Takahashi A
FAU - Kamatani, Naoyuki
AU  - Kamatani N
FAU - Kubo, Michiaki
AU  - Kubo M
FAU - Tsunoda, Tatsuhiko
AU  - Tsunoda T
FAU - Hata, Akira
AU  - Hata A
FAU - Nakamura, Yusuke
AU  - Nakamura Y
FAU - Tanaka, Toshihiro
AU  - Tanaka T
CN  - Japan Kawasaki Disease Genome Consortium
CN  - US Kawasaki Disease Genetics Consortium
LA  - eng
GR  - HL-06941/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120325
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (FCGR2A protein, human)
RN  - 0 (Genetic Markers)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - *Genetic Loci
MH  - *Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - *Genome-Wide Association Study
MH  - Humans
MH  - Mucocutaneous Lymph Node Syndrome/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Receptors, IgG/genetics
FIR - Abe, Jun
IR  - Abe J
FIR - Kobayashi, Tohru
IR  - Kobayashi T
FIR - Arakawa, Hirokazu
IR  - Arakawa H
FIR - Ichida, Fukiko
IR  - Ichida F
FIR - Nomura, Yuichi
IR  - Nomura Y
FIR - Miura, Masaru
IR  - Miura M
FIR - Ikeda, Kazuyuki
IR  - Ikeda K
FIR - Hara, Toshiro
IR  - Hara T
FIR - Fukazawa, Ryuji
IR  - Fukazawa R
FIR - Ogawa, Shunichi
IR  - Ogawa S
FIR - Hamaoka, Kenji
IR  - Hamaoka K
FIR - Newburger, Jane W
IR  - Newburger JW
FIR - Baker, Annette L
IR  - Baker AL
FIR - Rowley, Anne H
IR  - Rowley AH
FIR - Shulman, Stanford T
IR  - Shulman ST
FIR - Melish, Marian E
IR  - Melish ME
FIR - Mason, Wilbert H
IR  - Mason WH
FIR - Takahashi, Masato
IR  - Takahashi M
FIR - Tremoulet, Adriana H
IR  - Tremoulet AH
EDAT- 2012/03/27 06:00
MHDA- 2012/07/03 06:00
CRDT- 2012/03/27 06:00
PHST- 2011/08/26 00:00 [received]
PHST- 2012/02/24 00:00 [accepted]
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
AID - ng.2220 [pii]
AID - 10.1038/ng.2220 [doi]
PST - epublish
SO  - Nat Genet. 2012 Mar 25;44(5):517-21. doi: 10.1038/ng.2220.