PMID- 22447151
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20211021
IS  - 1432-1912 (Electronic)
IS  - 0028-1298 (Linking)
VI  - 385
IP  - 6
DP  - 2012 Jun
TI  - FLZ, synthetic squamosamide cyclic derivative, attenuates memory deficit and 
      pathological changes in mice with experimentally induced aging.
PG  - 579-85
LID - 10.1007/s00210-012-0745-z [doi]
AB  - The aim of this study was to investigate the protective effects of 
      N-[2-(4-hydroxy-phenyl)-ethyl]-2-(2,5-dimethoxy-phenyl)-3-(3-methoxy-4-hydroxy-phenyl)-acrylamide 
      (FLZ), a synthetic squamosamide cyclic derivative, on senescent mice induced by 
      D: -galactose/NaNO(2) (120/90 mg/kg, i.p.) once daily for 60 days. FLZ (75 and 
      150 mg/kg) was orally administered once daily for 30 days after D: 
      -galactose/NaNO(2) treatment for 30 days. The cognitive function of mice was 
      evaluated with step-down task. The brain biomarkers including monoamine oxidase B 
      (MAO-B), glutathione peroxidase (GSH-px), and malondialdehyde (MDA) were 
      determined according to the manufacturer's instructions. The expression of 
      acetylcholinesterase (ACh-E) and choline acetyltransferase (ChAT) protein in the 
      CA1 region of hippocampus were counted by immunohistochemical staining. The 
      results showed that the cognitive function, GSH-px activity in the brain, and the 
      expression of ACh-E and ChAT in the CA1 region of hippocampus were significantly 
      decreased, while MAO-B activity and MDA level in the brain were increased in 
      senescent mice compared with the control mice. FLZ treatment prolonged the 
      step-down latency and decreased the number of step-down errors in the senescent 
      mice. In addition, FLZ treatment increased the GSH-px activity and the expression 
      of ACh-E and ChAT in the hippocampus and decreased the MDA level and MAO-B 
      activity compared with the senescent mice without drug administration. These 
      findings suggested that FLZ improves the performance in the step-down task and 
      the pathological alternations in senescent mice.
FAU - Fang, Fang
AU  - Fang F
AD  - State Key Laboratory of Bioactive Substance and Function of Natural Medicines, 
      Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, China. fangf@bucm.edu.cn
FAU - Wang, Qing-li
AU  - Wang QL
FAU - Liu, Geng-tao
AU  - Liu GT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120324
PL  - Germany
TA  - Naunyn Schmiedebergs Arch Pharmacol
JT  - Naunyn-Schmiedeberg's archives of pharmacology
JID - 0326264
RN  - 0 (Benzeneacetamides)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Phenols)
RN  - 142750-35-4 (squamosamide)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.4.3.4 (Monoamine Oxidase)
RN  - M0KG633D4F (Sodium Nitrite)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Benzeneacetamides/pharmacology/*therapeutic use
MH  - Brain/drug effects/pathology/physiopathology
MH  - Disease Models, Animal
MH  - Galactose
MH  - Glutathione Peroxidase/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Memory Disorders/chemically induced/*drug therapy/physiopathology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Monoamine Oxidase/metabolism
MH  - Neurons/drug effects/pathology
MH  - Neuroprotective Agents/pharmacology/*therapeutic use
MH  - Phenols/pharmacology/*therapeutic use
MH  - Sodium Nitrite
EDAT- 2012/03/27 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/03/27 06:00
PHST- 2011/10/24 00:00 [received]
PHST- 2012/02/29 00:00 [accepted]
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - 10.1007/s00210-012-0745-z [doi]
PST - ppublish
SO  - Naunyn Schmiedebergs Arch Pharmacol. 2012 Jun;385(6):579-85. doi: 
      10.1007/s00210-012-0745-z. Epub 2012 Mar 24.