PMID- 22447491
OWN - NLM
STAT- MEDLINE
DCOM- 20121030
LR  - 20211021
IS  - 1433-0350 (Electronic)
IS  - 0256-7040 (Print)
IS  - 0256-7040 (Linking)
VI  - 28
IP  - 7
DP  - 2012 Jul
TI  - Brain volume and shape in infants with deformational plagiocephaly.
PG  - 1083-90
LID - 10.1007/s00381-012-1731-y [doi]
AB  - PURPOSE: Infants with deformational plagiocephaly (DP) have been shown to exhibit 
      developmental delays relative to unaffected infants. Although the mechanisms 
      accounting for these delays are unknown, one hypothesis focuses on underlying 
      differences in brain development. In this study, we used MRI to examine brain 
      volume and shape in infants with and without DP. METHODS: Participants included 
      20 infants with DP (mean age = 7.9 months, SD = 1.2; n = 12 male) and 21 controls 
      (mean age = 7.9 months, SD = 1.3; n = 11 male). Measures included volumes of the 
      total brain and cerebellum; midsagittal areas of the corpus callosum and 
      cerebellar vermis; and linear distance measures used to quantify the shape of 
      selected brain structures. We also evaluated the association between shape 
      measures and developmental scores on the Bayley Scales of Infant and Toddler 
      Development-III (BSID-III). RESULTS: Brain volume did not distinguish cases and 
      controls (p = .214-.976). However, cases exhibited greater asymmetry and 
      flattening of the posterior brain (p < .001-.002) and cerebellar vermis (p = 
      .035), shortening of the corpus callosum (p = .012), and differences in the 
      orientation of the corpus callosum (p = .005). Asymmetry and flattening of brain 
      structures were associated with worse developmental outcomes on the BSID-III. 
      CONCLUSIONS: Infants with DP show differences in brain shape, consistent with the 
      skull deformity characteristic of this condition, and shape measures were 
      associated with infant development. Longitudinal studies, beginning in the 
      neonatal period, are needed to clarify whether developmental effects precede or 
      follow brain deformation.
FAU - Collett, Brent R
AU  - Collett BR
AD  - Department of Psychiatry and Behavioral Sciences, University of Washington, 
      Seattle, WA, USA. bcollett@u.washington.edu
FAU - Aylward, Elizabeth H
AU  - Aylward EH
FAU - Berg, Jessica
AU  - Berg J
FAU - Davidoff, Candice
AU  - Davidoff C
FAU - Norden, Justin
AU  - Norden J
FAU - Cunningham, Michael L
AU  - Cunningham ML
FAU - Speltz, Matthew L
AU  - Speltz ML
LA  - eng
GR  - R01 HD046565/HD/NICHD NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - 1 R01 HD046565/HD/NICHD NIH HHS/United States
GR  - 1 UL1 RR025014/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120325
PL  - Germany
TA  - Childs Nerv Syst
JT  - Child's nervous system : ChNS : official journal of the International Society for 
      Pediatric Neurosurgery
JID - 8503227
SB  - IM
MH  - Age Factors
MH  - Brain/*growth & development/*pathology
MH  - Developmental Disabilities/*pathology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Infant
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Plagiocephaly, Nonsynostotic/*pathology
MH  - Severity of Illness Index
PMC - PMC3393042
MID - NIHMS386283
EDAT- 2012/03/27 06:00
MHDA- 2012/10/31 06:00
PMCR- 2013/07/01
CRDT- 2012/03/27 06:00
PHST- 2012/02/07 00:00 [received]
PHST- 2012/02/21 00:00 [accepted]
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/10/31 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - 10.1007/s00381-012-1731-y [doi]
PST - ppublish
SO  - Childs Nerv Syst. 2012 Jul;28(7):1083-90. doi: 10.1007/s00381-012-1731-y. Epub 
      2012 Mar 25.