PMID- 22447660
OWN - NLM
STAT- MEDLINE
DCOM- 20130129
LR  - 20120905
IS  - 1520-6394 (Electronic)
IS  - 1091-4269 (Linking)
VI  - 29
IP  - 9
DP  - 2012 Sep
TI  - Duration of last depressive episode may influence serum BDNF levels in remitted 
      patients with major depression.
PG  - 775-9
LID - 10.1002/da.21933 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) may have an important role 
      in the pathophysiology of depression. Previous studies indicate that serum BDNF 
      levels were lower in patients with depression and increased after treatment with 
      antidepressants. However, results of studies on serum BDNF levels in remitted 
      patients with depression have been inconsistent. The purpose of the present study 
      was to determine which factors influence the alteration of serum BDNF levels in 
      depression in the remitted state. METHODS: Serum BDNF levels were evaluated in 75 
      remitted inpatients with major depressive disorder (MDD) and 108 controls. 
      Multiple regression analyses were conducted using serum BDNF levels as the 
      dependent variable; and the number of episodes, Hamilton Rating Scale for 
      Depression score at admission, or duration of last depressive episode as 
      independent variables. RESULTS: Serum BDNF levels were lower in remitted patients 
      with MDD than in controls (P < .001). Multiple regression analysis showed a 
      significant effect between the duration of the last depressive episode and serum 
      BDNF levels (P < .022). CONCLUSIONS: Serum BDNF levels in remitted patients with 
      MDD did not recover to the level of healthy controls, and lower serum BDNF levels 
      were influenced by a longer duration of last depressive episode. It is possible 
      that persistent hippocampal reduction in remitted depression may be caused by 
      lower BDNF levels associated with a longer duration of the last depressive 
      episode.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Takebayashi, Naoko
AU  - Takebayashi N
AD  - Department of Psychiatry, Juntendo University, School of Medicine, 2-1-1 Hongo, 
      Bunkyo-ku, Tokyo, Japan.
FAU - Maeshima, Hitoshi
AU  - Maeshima H
FAU - Baba, Hajime
AU  - Baba H
FAU - Nakano, Yoshiyuki
AU  - Nakano Y
FAU - Satomura, Emi
AU  - Satomura E
FAU - Kita, Yohei
AU  - Kita Y
FAU - Namekawa, Yuki
AU  - Namekawa Y
FAU - Nomoto, Hiroshi
AU  - Nomoto H
FAU - Suzuki, Toshihito
AU  - Suzuki T
FAU - Arai, Heii
AU  - Arai H
LA  - eng
PT  - Journal Article
DEP - 20120323
PL  - United States
TA  - Depress Anxiety
JT  - Depression and anxiety
JID - 9708816
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antidepressive Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Depressive Disorder, Major/*blood/drug therapy/physiopathology
MH  - Female
MH  - Humans
MH  - Inpatients
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Regression Analysis
EDAT- 2012/03/27 06:00
MHDA- 2013/01/30 06:00
CRDT- 2012/03/27 06:00
PHST- 2011/11/20 00:00 [received]
PHST- 2012/01/15 00:00 [revised]
PHST- 2012/01/29 00:00 [accepted]
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2013/01/30 06:00 [medline]
AID - 10.1002/da.21933 [doi]
PST - ppublish
SO  - Depress Anxiety. 2012 Sep;29(9):775-9. doi: 10.1002/da.21933. Epub 2012 Mar 23.