PMID- 22447721
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20131121
IS  - 1099-0461 (Electronic)
IS  - 1095-6670 (Linking)
VI  - 26
IP  - 4
DP  - 2012 Mar-Apr
TI  - Effect of tin and lead chlorotriphenyl analogues on fruit fly Drosophila hydei 
      and liposomes membrane.
PG  - 162-7
LID - 10.1002/jbt.21403 [doi]
AB  - This article presents the results of a study investigating the biological 
      activity of triphenyltin chloride (TPhT) and two metalloorganic compounds, 
      triphenyllead chloride (TPhL) and triphenylmethane chloride (TPhC), in their 
      interaction with model membranes and the living organisms of fruit flies 
      Drosophila hydei. The study of model membranes (sonicated liposomes) was 
      conducted using the electron spin resonance (ESR) spin probe technique, whereas 
      the experiment on fruit flies involved investigating their viability on media 
      containing the studied compounds. The test results clearly demonstrate that TPhT 
      affects fruit flies more actively than TPhL (complete lethality after 7 days of 
      culture with a TPhT-containing medium). No toxic effect of TPhC on fruit flies 
      was shown. The results of the biological experiment were reflected in the 
      physical experiment involving an ESR study of liposomes: TPhT activity manifested 
      itself as a considerable increase in fluidity of the central region of the 
      liposome lipid bilayer.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Mitrus, Slawomir
AU  - Mitrus S
AD  - Department of Biosystematics, Opole University, Oleska 22, 45-052 Opole, Poland. 
      smitrus@uni.opole.pl
FAU - Man, Dariusz
AU  - Man D
LA  - eng
PT  - Journal Article
DEP - 20120323
PL  - United States
TA  - J Biochem Mol Toxicol
JT  - Journal of biochemical and molecular toxicology
JID - 9717231
RN  - 0 (Liposomes)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Organotin Compounds)
RN  - 0 (Trityl Compounds)
RN  - 1153-06-6 (triphenyllead chloride)
RN  - 2P299V784P (Lead)
RN  - 7440-31-5 (Tin)
RN  - 8O4UTW9E17 (triphenylmethane)
RN  - I1L80IDY27 (triphenyltin chloride)
SB  - IM
MH  - Animals
MH  - Cell Membrane/drug effects
MH  - Drosophila/*drug effects/metabolism
MH  - Electron Spin Resonance Spectroscopy
MH  - Lead/chemistry
MH  - Liposomes/*chemistry
MH  - Models, Animal
MH  - Organometallic Compounds/chemistry/*toxicity
MH  - Organotin Compounds/chemistry/*toxicity
MH  - Tin/chemistry
MH  - Trityl Compounds/chemistry/*toxicity
EDAT- 2012/03/27 06:00
MHDA- 2012/10/25 06:00
CRDT- 2012/03/27 06:00
PHST- 2011/10/03 00:00 [received]
PHST- 2011/11/29 00:00 [revised]
PHST- 2011/12/17 00:00 [accepted]
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - 10.1002/jbt.21403 [doi]
PST - ppublish
SO  - J Biochem Mol Toxicol. 2012 Mar-Apr;26(4):162-7. doi: 10.1002/jbt.21403. Epub 
      2012 Mar 23.