PMID- 22447860
OWN - NLM
STAT- MEDLINE
DCOM- 20120726
LR  - 20130109
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 53
IP  - 6
DP  - 2012 May 4
TI  - A comparison of HLA genotype with inflammation in uveal melanoma.
PG  - 2640-6
LID - 10.1167/iovs.11-8901 [doi]
AB  - PURPOSE: Human leukocyte antigen (HLA) polymorphisms have been associated with 
      the development of autoimmune diseases. In uveal melanoma, a high expression of 
      HLA classes I and II, and infiltration with lymphocytes and macrophages are 
      associated with a bad prognosis. Inflammation has an important role in this 
      malignancy. The goal of our study was to determine whether specific HLA alleles 
      are associated with increased inflammation. METHODS: Records were analyzed of 45 
      patients who underwent enucleation for uveal melanoma. HLA typing, tumor HLA 
      expression and tumor macrophage infiltration were determined in each case. 
      RESULTS: Before correction for multiple testing, macrophage infiltration was less 
      in HLA-A2 positive patients. Patients with HLA-DR6 had a higher tumor cell 
      expression of HLA-DR. After correction for the number of analyses, no 
      associations remained statistically significant. CONCLUSION: The results before 
      correction suggest that the HLA genotype may influence inflammation as indicated 
      by HLA expression and macrophage infiltration in uveal melanoma. However, after 
      correction this association did not prove significant.
FAU - van Essen, T Huibertus
AU  - van Essen TH
AD  - Department of Ophthalmology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Bronkhorst, Inge H G
AU  - Bronkhorst IH
FAU - Maat, Willem
AU  - Maat W
FAU - Verduyn, Willem
AU  - Verduyn W
FAU - Roelen, Dave L
AU  - Roelen DL
FAU - Luyten, Gregorius P M
AU  - Luyten GP
FAU - Jager, Martine J
AU  - Jager MJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120504
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - Chromosomes, Human, Pair 3/metabolism
MH  - Eye Enucleation
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - *Genotype
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Inflammation/*immunology
MH  - Macrophages/*physiology
MH  - Male
MH  - Melanoma/*genetics/immunology/surgery
MH  - Middle Aged
MH  - Uveal Neoplasms/*genetics/immunology/surgery
EDAT- 2012/03/27 06:00
MHDA- 2012/07/27 06:00
CRDT- 2012/03/27 06:00
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/07/27 06:00 [medline]
AID - iovs.11-8901 [pii]
AID - 10.1167/iovs.11-8901 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2012 May 4;53(6):2640-6. doi: 10.1167/iovs.11-8901.