PMID- 22447869
OWN - NLM
STAT- MEDLINE
DCOM- 20120712
LR  - 20220330
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 53
IP  - 6
DP  - 2012 May 9
TI  - Structure-function relationships between spectral-domain OCT and standard 
      achromatic perimetry.
PG  - 2740-8
LID - 10.1167/iovs.11-8320 [doi]
AB  - PURPOSE: To explore structure-function relationships in early glaucoma with 
      spectral-domain optical coherence tomography (SD-OCT) and standard achromatic 
      perimetry. METHODS: One hundred thirty-six eyes of 97 patients with suspected or 
      early glaucoma were enrolled from the clinical database at UCLA's Glaucoma 
      Division. All patients had good-quality peripapillary retinal nerve fiber layer 
      (RNFL)/optic disc measurements and a reliable 24-2 SITA-Standard Humphrey visual 
      field (VF) within a 6-month period. Correlations of global and sectoral RNFL 
      thickness and rim area (RA) measurements, with corresponding global and regional 
      VF sensitivities (both in logarithmic [dB] and 1/Lambert scales [1/L]), were 
      investigated with components of variance models. RESULTS: The average RNFL 
      thickness, RA, and mean deviation (MD) were 85.6 +/- 5.7 mu, 1.0 +/- 0.3 mm(2), and 
      -1.3 +/- 1.9 dB, respectively. Global RA demonstrated a stronger correlation with 
      MD compared to average RNFL thickness (P = 0.002). The highest correlations were 
      observed between superonasal VF cluster (in dB scale) and inferotemporal RA (R(2) 
      = 0.26, 95% CI: 0.15-0.40) or inferotemporal RNFL thickness (R(2) = 0.24, 95% CI: 
      0.13-0.37). In glaucoma suspects, the highest correlations were seen between 
      superonasal VF cluster and inferotemporal RA (R(2) = 0.16) in dB scale or RNFL 
      thickness (R(2) = 0.10) in 1/L scale. Correlations were slightly greater with dB 
      scale than 1/L scale and tended to be linear with both scales. CONCLUSIONS: 
      Structure-function relationships can be detected in early glaucoma with SD-OCT. 
      Correlations of RA with VF thresholds tended to be higher compared to those of 
      RNFL. Structure-function relationships were well described with a linear model.
FAU - Nilforushan, Naveed
AU  - Nilforushan N
AD  - Glaucoma Division, Jules Stein Eye Institute, UCLA, Los Angeles, California 
      90095, USA.
FAU - Nassiri, Nariman
AU  - Nassiri N
FAU - Moghimi, Sasan
AU  - Moghimi S
FAU - Law, Simon K
AU  - Law SK
FAU - Giaconi, JoAnn
AU  - Giaconi J
FAU - Coleman, Anne L
AU  - Coleman AL
FAU - Caprioli, Joseph
AU  - Caprioli J
FAU - Nouri-Mahdavi, Kouros
AU  - Nouri-Mahdavi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120509
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma/diagnosis/*physiopathology
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Ocular Hypertension/diagnosis/physiopathology
MH  - Optic Nerve Diseases/diagnosis/*physiopathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Tonometry, Ocular
MH  - Vision Disorders/physiopathology
MH  - Visual Field Tests/*methods
MH  - Visual Fields/*physiology
EDAT- 2012/03/27 06:00
MHDA- 2012/07/13 06:00
CRDT- 2012/03/27 06:00
PHST- 2012/03/27 06:00 [entrez]
PHST- 2012/03/27 06:00 [pubmed]
PHST- 2012/07/13 06:00 [medline]
AID - iovs.11-8320 [pii]
AID - 10.1167/iovs.11-8320 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2012 May 9;53(6):2740-8. doi: 10.1167/iovs.11-8320.