PMID- 22447958 OWN - NLM STAT- MEDLINE DCOM- 20130325 LR - 20120927 IS - 1532-2092 (Electronic) IS - 1099-5129 (Linking) VI - 14 IP - 10 DP - 2012 Oct TI - Heart failure in patients with sick sinus syndrome treated with single lead atrial or dual-chamber pacing: no association with pacing mode or right ventricular pacing site. PG - 1475-82 AB - AIMS: Previous studies indicate that ventricular pacing may precipitate heart failure (HF). We investigated occurrence of HF during long-term follow-up among patients with sick sinus syndrome (SSS) randomized to AAIR or DDDR pacing. Furthermore, we investigated effects of percentage of ventricular pacing (%VP) and pacing site in the ventricle. METHODS AND RESULTS: We analysed data from 1415 patients randomized to AAIR (n = 707) or DDDR pacing (n = 708). Ventricular pacing leads were recorded as located in either an apical or a non-apical position. The %VP and HF hospitalizations were recorded during follow-up. Patients were classified with new HF, if in New York Heart Association (NYHA) functional class IV or if presence of >/=2 of: oedema; dyspnoea; NYHA functional class III. Mean follow-up was 5.4 +/- 2.4 years. Heart failure hospitalizations did not differ between groups. In the AAIR group, 170 of the 707 (26%) patients developed HF vs. 169 of the 708 (26%) patients in the DDDR group, hazard rate ratio (HR) 1.00, 95% confidence interval (CI) 0.79-1.22, P = 0.87. In DDDR patients, 146 of the 512 patients (29%) with ventricular leads in an apical position developed HF vs. 28 of the 161 patients (17%) with the leads in a non-apical position, HR 0.67, CI 0.45-1.00, P = 0.05. After adjustments this difference was non-significant. The incidence of HF was not associated with %VP (P = 0.57). CONCLUSION: In patients with SSS, HF was not associated with pacing mode, %VP, or ventricular lead localization. This suggests that DDDR pacing is safe in patients with SSS without precipitating HF. FAU - Riahi, Sam AU - Riahi S AD - Department of Cardiology, Aalborg Hospital, Aalborg University Hospital, Hobrovej 16-18, Postbox 365, DK-9100 Aalborg, Denmark. FAU - Nielsen, Jens Cosedis AU - Nielsen JC FAU - Hjortshoj, Soren AU - Hjortshoj S FAU - Thomsen, Poul Erik B AU - Thomsen PE FAU - Hojberg, Soren AU - Hojberg S FAU - Moller, Mogens AU - Moller M FAU - Dalsgaard, Dorthe AU - Dalsgaard D FAU - Nielsen, Tonny AU - Nielsen T FAU - Asklund, Mogens AU - Asklund M FAU - Friis, Elsebeth V AU - Friis EV FAU - Christensen, Per D AU - Christensen PD FAU - Simonsen, Erik H AU - Simonsen EH FAU - Eriksen, Ulrik H AU - Eriksen UH FAU - Jensen, Gunnar V H AU - Jensen GV FAU - Svendsen, Jesper H AU - Svendsen JH FAU - Toff, William D AU - Toff WD FAU - Healey, Jeffrey S AU - Healey JS FAU - Andersen, Henning R AU - Andersen HR CN - DANPACE Investigators LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120323 PL - England TA - Europace JT - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology JID - 100883649 SB - IM MH - Aged MH - Aged, 80 and over MH - Cardiac Pacing, Artificial/*adverse effects/*methods MH - Dyspnea/diagnosis MH - Edema/diagnosis MH - Female MH - Follow-Up Studies MH - Heart Failure/epidemiology/*etiology MH - Hospitalization/statistics & numerical data MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Randomized Controlled Trials as Topic MH - Severity of Illness Index MH - Sick Sinus Syndrome/*therapy MH - Treatment Outcome FIR - Andersen, Henning Rud IR - Andersen HR FIR - Nielsen, Jens Cosedis IR - Nielsen JC FIR - Bloch-Thomsen, Poul-Erik IR - Bloch-Thomsen PE FIR - Moller, Mogens IR - Moller M FIR - Vesterlund, Thomas IR - Vesterlund T FIR - Dalsgaard, Dorthe IR - Dalsgaard D FIR - Nielsen, Tonny IR - Nielsen T FIR - Asklund, Mogens IR - Asklund M FIR - Friis, Elsebeth Vibeke IR - Friis EV FIR - Christensen, Per Dahl IR - Christensen PD FIR - Simonsen, Erik Hertel IR - Simonsen EH FIR - Eriksen, Ulrik Hedegaard IR - Eriksen UH FIR - Jensen, Gunnar Vagn Hagemann IR - Jensen GV FIR - Svendsen, Jesper Hastrup IR - Svendsen JH FIR - Toff, William D IR - Toff WD FIR - Skehan, J Douglas IR - Skehan JD FIR - Brack, Kieran IR - Brack K FIR - Barr, Craig IR - Barr C FIR - Tselios, Andreas IR - Tselios A FIR - Gordon, Nicola IR - Gordon N FIR - Cleland, John IR - Cleland J FIR - Clark, Andrew IR - Clark A FIR - Hurren, Sarah IR - Hurren S FIR - McEneaney, David IR - McEneaney D FIR - Moriarty, Andrew IR - Moriarty A FIR - Mackin, Anne IR - Mackin A FIR - Burton, Jane IR - Burton J FIR - Oliver, Ruth IR - Oliver R FIR - Kneale, Barry IR - Kneale B FIR - Huggins, Lynda IR - Huggins L FIR - Healey, Jeffrey S IR - Healey JS FIR - Parsonnet, Victor IR - Parsonnet V FIR - Barold, S Serge IR - Barold SS FIR - Furman, Seymour IR - Furman S FIR - Hayes, David L IR - Hayes DL FIR - Lamas, Gervasio A IR - Lamas GA FIR - Levine, Paul A IR - Levine PA FIR - Scheinman, Melvin M IR - Scheinman MM FIR - Camm, A John IR - Camm AJ FIR - Sutton, Richard IR - Sutton R FIR - Toff, William D IR - Toff WD FIR - Connolly, Stuart J IR - Connolly SJ FIR - Mugica, Jacques IR - Mugica J FIR - Thygesen, Kristian IR - Thygesen K FIR - Hayes, David L IR - Hayes DL FIR - Kappenberger, Lukas IR - Kappenberger L FIR - Schuller, Hans IR - Schuller H FIR - Mortensen, Leif Spange IR - Mortensen LS FIR - Videbaek, Jorgen IR - Videbaek J FIR - Egstrup, Kenneth IR - Egstrup K FIR - Bagger, Henning IR - Bagger H EDAT- 2012/03/27 06:00 MHDA- 2013/03/26 06:00 CRDT- 2012/03/27 06:00 PHST- 2012/03/27 06:00 [entrez] PHST- 2012/03/27 06:00 [pubmed] PHST- 2013/03/26 06:00 [medline] AID - eus069 [pii] AID - 10.1093/europace/eus069 [doi] PST - ppublish SO - Europace. 2012 Oct;14(10):1475-82. doi: 10.1093/europace/eus069. Epub 2012 Mar 23.