PMID- 22449226
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20220408
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 62
IP  - 4
DP  - 2012 Apr
TI  - A comparison of epidermal growth factor receptor expression in malignant 
      peritoneal and pleural mesothelioma.
PG  - 226-31
LID - 10.1111/j.1440-1827.2011.02778.x [doi]
AB  - An evaluation of epidermal growth factor receptor (EGFR) phenotypic expression in 
      malignant pleural and peritoneal mesothelioma was undertaken, using 
      immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) analysis. 
      Thirty-eight malignant mesothelioma (MM) specimens were subjected to IHC staining 
      and FISH to evaluate the expression of EGFR protein and gene status. Overall 
      positive IHC reaction was detected in 20/38 (53%) cases, in 11/22 (50%) pleural 
      MM, and in 9/16 (56%) peritoneal MM. Our study confirmed that EGFR membranous 
      expression is a common feature in MM, but not in benign mesothelial lesion. 
      Thirty-seven cases did not show a gene copy number gain. Only one case showed a 
      copy number gain. The protein overexpression of EGFR was not related to a gene 
      copy number gain.
CI  - (c) 2012 The Authors. Pathology International (c) 2012 Japanese Society of Pathology 
      and Blackwell Publishing Asia Pty Ltd.
FAU - Enomoto, Yasunori
AU  - Enomoto Y
AD  - Department of Diagnostic Pathology, Nara Medical University School of Medicine, 
      Nara, Japan.
FAU - Kasai, Takahiko
AU  - Kasai T
FAU - Takeda, Maiko
AU  - Takeda M
FAU - Takano, Masato
AU  - Takano M
FAU - Morita, Kouhei
AU  - Morita K
FAU - Kadota, Eiji
AU  - Kadota E
FAU - Iizuka, Norishige
AU  - Iizuka N
FAU - Maruyama, Hiroshi
AU  - Maruyama H
FAU - Haratake, Joji
AU  - Haratake J
FAU - Kojima, Yu
AU  - Kojima Y
FAU - Ikeda, Naoya
AU  - Ikeda N
FAU - Nonomura, Akitaka
AU  - Nonomura A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120130
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Genetic Markers)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*metabolism
MH  - DNA, Neoplasm/analysis
MH  - ErbB Receptors/genetics/*metabolism
MH  - Female
MH  - Gene Dosage
MH  - Gene Expression Regulation, Neoplastic
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mesothelioma/genetics/*metabolism/pathology
MH  - Middle Aged
MH  - Peritoneal Neoplasms/genetics/*metabolism/pathology
MH  - Pleural Neoplasms/genetics/*metabolism/pathology
EDAT- 2012/03/28 06:00
MHDA- 2012/07/20 06:00
CRDT- 2012/03/28 06:00
PHST- 2012/03/28 06:00 [entrez]
PHST- 2012/03/28 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 10.1111/j.1440-1827.2011.02778.x [doi]
PST - ppublish
SO  - Pathol Int. 2012 Apr;62(4):226-31. doi: 10.1111/j.1440-1827.2011.02778.x. Epub 
      2012 Jan 30.