PMID- 2244969
OWN - NLM
STAT- MEDLINE
DCOM- 19910109
LR  - 20190824
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 39
IP  - 3
DP  - 1990 Aug 20
TI  - Role of the hippocampus in temporal and spatial navigation: an adaptive neural 
      network.
PG  - 205-29
AB  - The hippocampus has been proposed to participate in either spatial or temporal 
      mapping. As an alternative to these seemingly conflicting views, we hypothesized 
      that the hippocampus computes 'aggregate predictions' of environmental events 
      that are used to control associative learning. Aggregate predictions forecast 
      what event is going to occur, when in time, and where in space. The hypothesis 
      assumes that activity of hippocampal pyramidal neurons is proportional to the 
      instantaneous value of the aggregate prediction, and that the computation of the 
      aggregate prediction is impaired by hippocampal lesions. In order to test the 
      'aggregate prediction' hypothesis in both spatial and temporal tasks, this paper 
      presents a real-time neural network capable of describing temporal discrimination 
      and spatial learning in a unified fashion. The neural network incorporates 
      detectors that can be tuned to a particular value of continuous temporal or 
      spatial variables. In the temporal domain, computer simulations were carried out 
      for temporal discrimination in classical conditioning and instrumental learning, 
      classical conditioning under different interstimulus intervals (ISIs), and 
      classical conditioning with mixed ISIs. In the spatial domain, computer 
      simulations were carried out for place and cue learning. The paper shows that 
      under the 'aggregate prediction' hypothesis the network correctly describes 
      activity of hippocampal pyramidal neurons and the effect of hippocampal lesions 
      in temporal and spatial learning. These results suggest that, rather than either 
      a temporal or spatial function, the hippocampus is involved in the computation of 
      variables common to both temporal and spatial navigation.
FAU - Schmajuk, N A
AU  - Schmajuk NA
AD  - Department of Psychology, Northwestern University, Evanston, IL 60201.
LA  - eng
GR  - SO7 RR07028-22/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
SB  - IM
MH  - Animals
MH  - Association Learning/*physiology
MH  - Computer Simulation
MH  - Hippocampus/*physiology
MH  - Models, Neurological
MH  - Nerve Net/*physiology
MH  - Neurons/physiology
MH  - Orientation/*physiology
MH  - Psychomotor Performance/*physiology
MH  - Rats
MH  - Social Environment
MH  - Space Perception/*physiology
MH  - Time Perception/*physiology
RF  - 92
EDAT- 1990/08/20 00:00
MHDA- 1990/08/20 00:01
CRDT- 1990/08/20 00:00
PHST- 1990/08/20 00:00 [pubmed]
PHST- 1990/08/20 00:01 [medline]
PHST- 1990/08/20 00:00 [entrez]
AID - 0166-4328(90)90028-D [pii]
AID - 10.1016/0166-4328(90)90028-d [doi]
PST - ppublish
SO  - Behav Brain Res. 1990 Aug 20;39(3):205-29. doi: 10.1016/0166-4328(90)90028-d.