PMID- 22450656
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20120808
IS  - 1572-8781 (Electronic)
IS  - 1387-2176 (Linking)
VI  - 14
IP  - 4
DP  - 2012 Aug
TI  - A lithography-free procedure for fabricating three-dimensional microchannels 
      using hydrogel molds.
PG  - 689-97
LID - 10.1007/s10544-012-9649-4 [doi]
AB  - We present a lithography-free procedure for fabricating intrinsically 
      three-dimensional smooth-walled microchannels within poly(dimethylsiloxane) 
      (PDMS) elastomer using hydrogel molds. In the fabrication process, small pieces 
      of agarose gel ("wires" or "chips") are embedded in uncured PDMS composite, 
      arranged in the shape of the desired microchannels, and used as molds to form the 
      microchannels. The point of the process is that molds for creating junctions of 
      microchannels such as T-junctions or cross-junctions can be robustly formed by 
      simply grafting gel wires in uncured PDMS composite without using adhesive 
      agents. The technical advantage of this method is that three-dimensional 
      microstructures such as microchannels with circular cross sections, 
      three-dimensionally arranged junctions or interchanges of microchannels can be 
      flexibly designed and fabricated with a straightforward procedure without the 
      need for any specialized equipment or layer-by-layer assemblage processes. This 
      method provides a low-cost, green procedure for fabricating microfluidic devices 
      and promises to make microfluidic processes more accessible and easy to implement 
      in a variety of scientific fields.
FAU - Hirama, Hirotada
AU  - Hirama H
AD  - Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha, 
      Kashiwa, Japan.
FAU - Odera, Takahiro
AU  - Odera T
FAU - Torii, Toru
AU  - Torii T
FAU - Moriguchi, Hiroyuki
AU  - Moriguchi H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biomed Microdevices
JT  - Biomedical microdevices
JID - 100887374
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Elastomers)
RN  - 0 (Hydrogels)
RN  - 63148-62-9 (baysilon)
RN  - 9012-36-6 (Sepharose)
SB  - IM
MH  - Dimethylpolysiloxanes/chemistry
MH  - Elastomers/chemistry
MH  - Hydrogels/*chemistry
MH  - Microfluidic Analytical Techniques/economics/*methods
MH  - Sepharose/chemistry
EDAT- 2012/03/28 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/03/28 06:00
PHST- 2012/03/28 06:00 [entrez]
PHST- 2012/03/28 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - 10.1007/s10544-012-9649-4 [doi]
PST - ppublish
SO  - Biomed Microdevices. 2012 Aug;14(4):689-97. doi: 10.1007/s10544-012-9649-4.