PMID- 22451239
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20221207
IS  - 1573-7284 (Electronic)
IS  - 0393-2990 (Print)
IS  - 0393-2990 (Linking)
VI  - 27
IP  - 5
DP  - 2012 May
TI  - Association between bone mineral density and type 2 diabetes mellitus: a 
      meta-analysis of observational studies.
PG  - 319-32
LID - 10.1007/s10654-012-9674-x [doi]
AB  - Type 2 diabetes mellitus (T2DM) influences bone metabolism, but the relation of 
      T2DM with bone mineral density (BMD) remains inconsistent across studies. The 
      objective of this study was to perform a meta-analysis and meta-regression of the 
      literature to estimate the difference in BMD (g/cm(2)) between diabetic and 
      non-diabetic populations, and to investigate potential underlying mechanisms. A 
      literature search was performed in PubMed and Ovid extracting data from articles 
      prior to May 2010. Eligible studies were those where the association between T2DM 
      and BMD measured by dual energy X-ray absorptiometry was evaluated using a 
      cross-sectional, cohort or case-control design, including both healthy controls 
      and subjects with T2DM. The analysis was done on 15 observational studies (3,437 
      diabetics and 19,139 controls). Meta-analysis showed that BMD in diabetics was 
      significantly higher, with pooled mean differences of 0.04 (95% CI: 0.02, 0.05) 
      at the femoral neck, 0.06 (95% CI: 0.04, 0.08) at the hip and 0.06 (95% CI: 0.04, 
      0.07) at the spine. The differences for forearm BMD were not significantly 
      different between diabetics and non-diabetics. Sex-stratified analyses showed 
      similar results in both genders. Substantial heterogeneity was found to originate 
      from differences in study design and possibly diabetes definition. Also, by 
      applying meta-regression we could establish that younger age, male gender, higher 
      body mass index and higher HbA(1C) were positively associated with higher BMD 
      levels in diabetic individuals. We conclude that individuals with T2DM from both 
      genders have higher BMD levels, but that multiple factors influence BMD in 
      individuals with T2DM.
FAU - Ma, Lili
AU  - Ma L
AD  - Department of Rheumatology, Fudan University, Shanghai, China.
FAU - Oei, Ling
AU  - Oei L
FAU - Jiang, Lindi
AU  - Jiang L
FAU - Estrada, Karol
AU  - Estrada K
FAU - Chen, Huiyong
AU  - Chen H
FAU - Wang, Zhen
AU  - Wang Z
FAU - Yu, Qiang
AU  - Yu Q
FAU - Zillikens, Maria Carola
AU  - Zillikens MC
FAU - Gao, Xin
AU  - Gao X
FAU - Rivadeneira, Fernando
AU  - Rivadeneira F
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20120327
PL  - Netherlands
TA  - Eur J Epidemiol
JT  - European journal of epidemiology
JID - 8508062
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Age Factors
MH  - Biomarkers/metabolism
MH  - Body Mass Index
MH  - *Bone Density
MH  - Diabetes Mellitus, Type 2/metabolism/*physiopathology
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Regression Analysis
MH  - Sex Factors
PMC - PMC3374119
EDAT- 2012/03/28 06:00
MHDA- 2012/10/16 06:00
PMCR- 2012/03/27
CRDT- 2012/03/28 06:00
PHST- 2011/09/17 00:00 [received]
PHST- 2012/03/01 00:00 [accepted]
PHST- 2012/03/28 06:00 [entrez]
PHST- 2012/03/28 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
PHST- 2012/03/27 00:00 [pmc-release]
AID - 9674 [pii]
AID - 10.1007/s10654-012-9674-x [doi]
PST - ppublish
SO  - Eur J Epidemiol. 2012 May;27(5):319-32. doi: 10.1007/s10654-012-9674-x. Epub 2012 
      Mar 27.