PMID- 22451839
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1735-3408 (Electronic)
IS  - 1735-143X (Print)
IS  - 1735-143X (Linking)
VI  - 12
IP  - 1
DP  - 2012 Jan
TI  - Association of hepatitis C virus with insulin resistance: evidences from animal 
      studies and clinical studies.
PG  - 11-5
AB  - CONTEXT: HCV infection is strongly associated with development of insulin 
      resistance and type-2 diabetes, however molecular mechanism of these associations 
      is not known. The aim of this review was to conduct a comprehensive literature 
      search to understand the nature of the association between hepatitis C virus 
      (HCV) infection and insulin resistance (IR). We also explored the role of HCV 
      core protein and NS5a in modulating the course of the insulin-signaling pathway. 
      EVIDENCE ACQUISITIONS: We searched Directory of Open Access Journals (DOAJ) 
      Google Scholar, Pubmed (NLM), LISTA (EBSCO), Web of Science (TS and PakMediNet). 
      RESULTS: Emerging evidence suggests an association between HCV infection and 
      carotid/coronary vascular disease. IR appears to be a dominant underlying cause 
      of accelerated atherosclerosis in patients with chronic hepatitis C (CHC). HCV 
      can induce IR directly through the stimulation of SOCS3 and PPA2, and both of 
      these molecules have been shown to inhibit interferon-alpha signaling. Improvement of 
      insulin sensitivity may increase the response rate to antiviral treatment and 
      prevent IR complications, including vascular diseases. The results of several 
      clinical trials that have used insulin sensitizers (metformin and PPAR-gamma 
      agonists) have been inconclusive. CONCLUSIONS: Beside the association between HCV 
      and IR, the published data also have showed the possible association of HCV core 
      and NS5A protein with IR.
FAU - Badar, Sadaf
AU  - Badar S
AD  - National Centre of Excellence in Molecular Biology, University of the Punjab, 
      Lahore, Pakistan.
FAU - Khubaib, Bushra
AU  - Khubaib B
FAU - Idrees, Muhammad
AU  - Idrees M
FAU - Hussain, Abrar
AU  - Hussain A
FAU - Awan, Zunaira
AU  - Awan Z
FAU - Butt, Sadia
AU  - Butt S
FAU - Afzal, Samia
AU  - Afzal S
FAU - Akram, Madeeha
AU  - Akram M
FAU - Fatima, Zareen
AU  - Fatima Z
FAU - Aftab, Mahwish
AU  - Aftab M
FAU - Saleem, Sana
AU  - Saleem S
FAU - Munir, Sara
AU  - Munir S
FAU - Rauff, Bisma
AU  - Rauff B
FAU - Naudhani, Mahrukh
AU  - Naudhani M
FAU - Ali, Liaquat
AU  - Ali L
FAU - Ali, Muhammaad
AU  - Ali M
FAU - Rehman, Irshadul
AU  - Rehman I
LA  - eng
PT  - Journal Article
DEP - 20120120
PL  - Netherlands
TA  - Hepat Mon
JT  - Hepatitis monthly
JID - 101277874
PMC - PMC3298871
OTO - NOTNLM
OT  - Hepatitis C
OT  - Insulin Resistance
OT  - NS5a Protein
EDAT- 2012/03/28 06:00
MHDA- 2012/03/28 06:01
PMCR- 2012/01/01
CRDT- 2012/03/28 06:00
PHST- 2011/01/12 00:00 [received]
PHST- 2011/12/13 00:00 [revised]
PHST- 2011/12/28 00:00 [accepted]
PHST- 2012/03/28 06:00 [entrez]
PHST- 2012/03/28 06:00 [pubmed]
PHST- 2012/03/28 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
PST - ppublish
SO  - Hepat Mon. 2012 Jan;12(1):11-5. Epub 2012 Jan 20.