PMID- 22453653
OWN - NLM
STAT- MEDLINE
DCOM- 20130905
LR  - 20121203
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 33
IP  - 23
DP  - 2012 Dec
TI  - Intracoronary microparticles and microvascular obstruction in patients with ST 
      elevation myocardial infarction undergoing primary percutaneous intervention.
PG  - 2928-38
LID - 10.1093/eurheartj/ehs065 [doi]
AB  - AIMS: Microparticles (MP) are cell-derived fragments known to be increased in the 
      blood of patients with acute coronary syndromes. We aimed to assess, in ST 
      elevation myocardial infarction (STEMI), the systemic and local (in the culprit 
      coronary artery) levels of platelet-derived MP (PMP, CD42+CD31+) and 
      endothelial-derived MP (EMP, CD42-CD31+) and their relation to indexes of 
      microvascular obstruction (MVO). METHODS AND RESULTS: In 78 STEMI patients 
      undergoing successful primary percutaneous coronary intervention, blood samples 
      were sequentially drawn from the aorta and the culprit coronary artery for 
      cytofluorimetric MP detection. Thrombolysis in myocardial infarction (TIMI) flow, 
      thrombus score (TS), corrected TIMI frame count (cTFC), myocardial blush grade 
      (MBG), quantitative blush evaluator (QuBE) score, and 90 min ST resolution (SigmaSTR) 
      were calculated. Both PMP and EMP levels were significantly higher in the 
      intracoronary than in the aortic blood samples. Intracoronary PMP and EMP levels 
      were positively related to TS and cTFC and inversely related to MBG and QuBE. 
      Aortic PMP (but not EMP) levels were related to TS and cTFC and, inversely, to 
      QuBE. Intracoronary PMP were independently related to angiographic and 
      electrocardiographic MVO in a multivariate model. CONCLUSION: The correlations of 
      intracoronary EMP and of both systemic and intracoronary PMP levels with TS 
      support the role of MP as markers of ongoing thrombosis. Moreover, the 
      correlation of intracoronary MP with indexes of microvascular dysfunction 
      suggests, for the first time, a possible direct role of MP in the pathogenesis of 
      MVO.
FAU - Porto, Italo
AU  - Porto I
AD  - Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, 
      L.go A. Gemelli, 8, 00168 Rome, Italy. italo.porto@gmail.com
FAU - Biasucci, Luigi Marzio
AU  - Biasucci LM
FAU - De Maria, Giovanni Luigi
AU  - De Maria GL
FAU - Leone, Antonio Maria
AU  - Leone AM
FAU - Niccoli, Giampaolo
AU  - Niccoli G
FAU - Burzotta, Francesco
AU  - Burzotta F
FAU - Trani, Carlo
AU  - Trani C
FAU - Tritarelli, Alessandra
AU  - Tritarelli A
FAU - Vergallo, Rocco
AU  - Vergallo R
FAU - Liuzzo, Giovanna
AU  - Liuzzo G
FAU - Crea, Filippo
AU  - Crea F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120327
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Analysis of Variance
MH  - Blood Platelets/*pathology
MH  - Cell-Derived Microparticles/*pathology
MH  - Coronary Occlusion/pathology
MH  - Coronary Thrombosis/pathology
MH  - Endothelium, Vascular/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Microcirculation/physiology
MH  - Microvessels
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardial Infarction/*pathology/therapy
MH  - Myocardial Reperfusion
MH  - Percutaneous Coronary Intervention
MH  - Prospective Studies
EDAT- 2012/03/29 06:00
MHDA- 2013/09/06 06:00
CRDT- 2012/03/29 06:00
PHST- 2012/03/29 06:00 [entrez]
PHST- 2012/03/29 06:00 [pubmed]
PHST- 2013/09/06 06:00 [medline]
AID - ehs065 [pii]
AID - 10.1093/eurheartj/ehs065 [doi]
PST - ppublish
SO  - Eur Heart J. 2012 Dec;33(23):2928-38. doi: 10.1093/eurheartj/ehs065. Epub 2012 
      Mar 27.