PMID- 22453841
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20211021
IS  - 1420-908X (Electronic)
IS  - 1023-3830 (Linking)
VI  - 61
IP  - 7
DP  - 2012 Jul
TI  - Evaluation of N-acetylcysteine treatment in acute pancreatitis-induced lung 
      injury.
PG  - 699-705
LID - 10.1007/s00011-012-0462-6 [doi]
AB  - OBJECTIVE: Pulmonary complications are frequent during acute pancreatitis (AP). 
      We investigate the effects of N-acetylcysteine (NAC) on lung injury in mild and 
      severe AP. ANIMALS AND TREATMENT: Mild and severe AP was induced in rats by 
      bile-pancreatic duct obstruction (BPDO) and infusion of 3.5 % sodium taurocholate 
      (NaTc) into the bile-pancreatic duct, respectively. NAC (50 mg/kg) was given 1 h 
      before and 1 h after AP. METHODS: Amylase activity was measured in plasma. Lungs 
      were harvested for mRNA expression analysis of monocyte chemoattractant protein-1 
      (MCP-1), cytokine-induced neutrophil chemoattractant (CINC), P-selectin and 
      intercellular adhesion molecule-1 (ICAM-1), myeloperoxidase (MPO) activity and 
      histological examination. RESULTS: Hyperamylasemia was reduced by NAC in both AP 
      models. NAC down-regulated MCP-1, CINC and P-selectin in BPDO- but not in 
      NaTc-induced AP. Pulmonary insults did not vary in mild AP and were exacerbated 
      in severe AP by NAC treatment. NAC reduced lung MPO activity in mild but not in 
      severe AP. CONCLUSIONS: Although NAC treatment down-regulated inflammatory 
      mediators in lungs during AP it did not prevent leukocyte infiltration, which 
      could be responsible for maintaining the lung injury. As a result, NAC aggravated 
      the lung damage in severe AP and failed to exert beneficial effects in the mild 
      disease model.
FAU - Yubero, Sara
AU  - Yubero S
AD  - Departamento Fisiologia y Farmacologia-IBSAL, University of Salamanca, Edificio 
      Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
FAU - Ramudo, Laura
AU  - Ramudo L
FAU - Manso, Manuel A
AU  - Manso MA
FAU - Collia, Francisco
AU  - Collia F
FAU - De Dios, Isabel
AU  - De Dios I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120323
PL  - Switzerland
TA  - Inflamm Res
JT  - Inflammation research : official journal of the European Histamine Research 
      Society ... [et al.]
JID - 9508160
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL1)
RN  - 0 (Cxcl1 protein, rat)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (RNA, Messenger)
RN  - 5E090O0G3Z (Taurocholic Acid)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 3.2.1.- (Amylases)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*therapeutic use
MH  - Amylases/blood
MH  - Animals
MH  - Chemokine CCL2/genetics
MH  - Chemokine CXCL1/genetics
MH  - Disease Models, Animal
MH  - Free Radical Scavengers/*therapeutic use
MH  - Lung/metabolism/pathology
MH  - Lung Injury/*drug therapy/etiology/metabolism/pathology
MH  - Male
MH  - Pancreatitis/chemically induced/*complications/metabolism/pathology
MH  - Peroxidase/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Taurocholic Acid
EDAT- 2012/03/29 06:00
MHDA- 2012/10/17 06:00
CRDT- 2012/03/29 06:00
PHST- 2012/01/10 00:00 [received]
PHST- 2012/03/07 00:00 [accepted]
PHST- 2012/02/08 00:00 [revised]
PHST- 2012/03/29 06:00 [entrez]
PHST- 2012/03/29 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - 10.1007/s00011-012-0462-6 [doi]
PST - ppublish
SO  - Inflamm Res. 2012 Jul;61(7):699-705. doi: 10.1007/s00011-012-0462-6. Epub 2012 
      Mar 23.