PMID- 22453969
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20161109
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 740
DP  - 2012
TI  - Regulation of intercellular calcium signaling through calcium interactions with 
      connexin-based channels.
PG  - 777-94
LID - 10.1007/978-94-007-2888-2_34 [doi]
AB  - The synchronization of numerous cellular events requires complex electric and 
      metabolic cell-cell interactions. Connexins are a family of membrane proteins 
      that constitute the molecular basis of two kinds of channels: gap junction 
      channels (GJCs), which allow direct cytoplasm-cytoplasm communication, and 
      hemichannels (HCs) that provide a pathway for exchanges between the intra and 
      extra-cellular milieu. Both kind of connexin-based channels support intercellular 
      communication via intercellular propagation of calcium waves. Here, we review 
      evidence supporting the role of Ca(2+) in the regulation of GJCs and HCs formed 
      by connexins. Also it is speculated how these connexin-based channels could 
      contribute to the propagation of intercellular Ca(2+) signals.
FAU - Orellana, Juan A
AU  - Orellana JA
AD  - Departamento de Neurologia, Facultad de Medicina, Pontificia Universidad Catolica 
      de Chile, Marcoleta 391, 8330024, Santiago, Chile. jaorella@uc.cl
FAU - Sanchez, Helmuth A
AU  - Sanchez HA
FAU - Schalper, Kurt A
AU  - Schalper KA
FAU - Figueroa, Vania
AU  - Figueroa V
FAU - Saez, Juan C
AU  - Saez JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Connexins)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/*metabolism
MH  - Calcium Signaling/*physiology
MH  - Cell Communication
MH  - Connexins/*physiology
MH  - Gap Junctions/physiology
MH  - Humans
MH  - Ion Channel Gating
EDAT- 2012/03/29 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/03/29 06:00
PHST- 2012/03/29 06:00 [entrez]
PHST- 2012/03/29 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - 10.1007/978-94-007-2888-2_34 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2012;740:777-94. doi: 10.1007/978-94-007-2888-2_34.