PMID- 22454252
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20151119
IS  - 1439-0795 (Electronic)
IS  - 0176-3679 (Linking)
VI  - 45
IP  - 6
DP  - 2012 Sep
TI  - A study of brain and serum brain-derived neurotrophic factor protein in Wistar 
      and Wistar-Kyoto rat strains after electroconvulsive stimulus.
PG  - 244-9
LID - 10.1055/s-0032-1306278 [doi]
AB  - BACKGROUND: Serum brain-derived neurotrophic factor (BDNF) protein has been 
      related to depression and less consistently to its treatments in human studies. 
      However, animal studies have failed to demonstrate a clear link between BDNF 
      protein in serum and brain tissue. METHODS: Serum and brain tissue levels of BDNF 
      protein were measured with ELISA in the Wistar-Kyoto (WKY) and Wistar strains at 
      1 and 7 days after 5 daily electroconvulsive stimulus sessions or sham 
      treatments. RESULTS: The WKY strain showed lower baseline serum BDNF protein 
      relative to Wistar controls. After 5 electroconvulsive stimuli, BDNF protein 
      density was significantly increased in hippocampus and cortical regions, but not 
      in the cerebellum or in serum. A clear correlation between brain and serum BDNF 
      was not observed in either strain or treatment group. DISCUSSION: Despite lower 
      baseline serum BDNF protein in the WKY strain, a lack of change in serum BDNF 
      after electroconvulsive stimulus and a lack of correlation between brain and 
      serum BDNF protein calls into question the relevance of serum BDNF as a measure 
      of depression and treatment response.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Kyeremanteng, C
AU  - Kyeremanteng C
AD  - Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, 
      Canada. ckyeremanteng@gmail.com
FAU - James, J
AU  - James J
FAU - Mackay, J
AU  - Mackay J
FAU - Merali, Z
AU  - Merali Z
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120327
PL  - Germany
TA  - Pharmacopsychiatry
JT  - Pharmacopsychiatry
JID - 8402938
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/blood/metabolism/therapy
MH  - Disease Models, Animal
MH  - Electroconvulsive Therapy/*methods/statistics & numerical data
MH  - Male
MH  - Rats
MH  - Rats, Inbred WKY/*blood
MH  - Rats, Wistar/*blood
MH  - Serum/*metabolism
MH  - Species Specificity
EDAT- 2012/03/29 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/03/29 06:00
PHST- 2012/03/29 06:00 [entrez]
PHST- 2012/03/29 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 10.1055/s-0032-1306278 [doi]
PST - ppublish
SO  - Pharmacopsychiatry. 2012 Sep;45(6):244-9. doi: 10.1055/s-0032-1306278. Epub 2012 
      Mar 27.