PMID- 22454660
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Print)
IS  - 1741-427X (Linking)
VI  - 2012
DP  - 2012
TI  - Electroacupuncture suppresses discrete cue-evoked heroin-seeking and fos protein 
      expression in the nucleus accumbens core in rats.
PG  - 286404
LID - 10.1155/2012/286404 [doi]
LID - 286404
AB  - Relapse to drug seeking was studied using a rodent model of reinstatement induced 
      by exposure to drug-related cues. Here, we used intravenous drug 
      self-administration procedures in rats to further investigate the beneficial 
      effects of electroacupuncture (EA) on heroin-seeking behavior in a reinstatement 
      model of relapse. We trained Sprague-Dawley rats to nose-poke for i.v. heroin 
      either daily for 4 h or 25 infusions for 14 consecutive days. Then the rats were 
      abstinent from heroin for two weeks. 2 Hz EA stimulation was conducted once daily 
      for 14 days during heroin abstinence. We tested these animals for contextual and 
      discrete cue-induced reinstatement of active responses. We also applied 
      immunohistochemistry to detect Fos-positive nuclei in the nucleus accumbens 
      (NACc) core and shell after reinstatement test. We found that active responses 
      elicited by both contextual cues and discrete cues were high in the rats trained 
      with heroin than in saline controls. EA treatment significantly reduced active 
      responses elicited by discrete cues. EA stimulation attenuated Fos expression in 
      the core but not the shell of the NACc. Altogether, these results highlight the 
      therapeutic benefit of EA in preventing relapse to drug addiction.
FAU - Liu, Sheng
AU  - Liu S
AD  - Ningbo Addiction Research and Treatment Center, School of Medicine, Ningbo 
      University, Ningbo 315010, China.
FAU - Zhu, Fenglei
AU  - Zhu F
FAU - Lai, Miaojun
AU  - Lai M
FAU - Sun, Limin
AU  - Sun L
FAU - Liu, Yijun
AU  - Liu Y
FAU - Zhou, Wenhua
AU  - Zhou W
LA  - eng
PT  - Journal Article
DEP - 20120214
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3290998
EDAT- 2012/03/29 06:00
MHDA- 2012/03/29 06:01
PMCR- 2012/02/14
CRDT- 2012/03/29 06:00
PHST- 2011/05/23 00:00 [received]
PHST- 2011/09/08 00:00 [revised]
PHST- 2011/10/26 00:00 [accepted]
PHST- 2012/03/29 06:00 [entrez]
PHST- 2012/03/29 06:00 [pubmed]
PHST- 2012/03/29 06:01 [medline]
PHST- 2012/02/14 00:00 [pmc-release]
AID - 10.1155/2012/286404 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2012;2012:286404. doi: 10.1155/2012/286404. 
      Epub 2012 Feb 14.