PMID- 22454669
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Print)
IS  - 1741-427X (Linking)
VI  - 2012
DP  - 2012
TI  - Effects of Electroacupuncture on N-Methyl-D-aspartate Receptor-Related Signaling 
      Pathway in the Spinal Cord of Normal Rats.
PG  - 492471
LID - 10.1155/2012/492471 [doi]
LID - 492471
AB  - This study examined the influence of the N-methyl-D-aspartate receptor (NMDAR) on 
      the modulation of related spinal signaling after electroacupuncture (EA) 
      treatment in normal rats. Bilateral 2 Hz EA stimulations (1-2-3.0 mA) were 
      delivered at acupoints corresponding to Zusanli (ST36) and Sanyinjiao (SP6) in 
      men for 30 min. Thermal sensitization was strongly inhibited by EA, but this 
      analgesia was reduced by preintrathecal injection of the NMDAR antagonist, MK801. 
      Phosphorylation of the NMDAR NR2B subunit, cAMP response element-binding protein 
      (CREB), and especially phosphatidylinositol 3-kinase (PI3K) were significantly 
      induced by EA. However, these marked phosphorylations were not observed in 
      MK801-pretreated rats. EA analgesia was reduced by preintrathecal injection with 
      the calcium chelators Quin2 and TMB8, similar to the results evident using MK801. 
      Phosphorylation of PI3K and CREB induced by EA was also inhibited by TMB8. 
      Calcium influx by NMDAR activation may play an important role in EA analgesia of 
      normal rats through the modulation of the phosphorylation of spinal PI3K and 
      CREB.
FAU - Kim, Ha-Neui
AU  - Kim HN
AD  - Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan 
      National University, Yangsan 626-870, Republic of Korea.
FAU - Kim, Yu-Ri
AU  - Kim YR
FAU - Jang, Ji-Yeon
AU  - Jang JY
FAU - Shin, Hwa-Kyoung
AU  - Shin HK
FAU - Choi, Byung-Tae
AU  - Choi BT
LA  - eng
PT  - Journal Article
DEP - 20120208
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3290892
EDAT- 2012/03/29 06:00
MHDA- 2012/03/29 06:01
PMCR- 2012/02/08
CRDT- 2012/03/29 06:00
PHST- 2011/04/20 00:00 [received]
PHST- 2011/09/29 00:00 [revised]
PHST- 2011/10/26 00:00 [accepted]
PHST- 2012/03/29 06:00 [entrez]
PHST- 2012/03/29 06:00 [pubmed]
PHST- 2012/03/29 06:01 [medline]
PHST- 2012/02/08 00:00 [pmc-release]
AID - 10.1155/2012/492471 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2012;2012:492471. doi: 10.1155/2012/492471. 
      Epub 2012 Feb 8.