PMID- 22455866 OWN - NLM STAT- MEDLINE DCOM- 20121106 LR - 20181201 IS - 1879-0844 (Electronic) IS - 1388-9842 (Linking) VI - 14 IP - 7 DP - 2012 Jul TI - The efficacy of renal angioplasty in patients with renal artery stenosis and flash oedema or congestive heart failure: a systematic review. PG - 773-81 LID - 10.1093/eurjhf/hfs037 [doi] AB - AIMS: Recent randomized controlled trials have reported that angioplasty does not have a beneficial effect compared with pharmacological treatment on blood pressure and renal function in patients with atherosclerotic renal artery stenosis (RAS). We aimed to explore systematically the evidence that angioplasty is effective in subgroups of patients with RAS and either flash pulmonary oedema or congestive heart failure (CHF) and renal insufficiency. METHODS AND RESULTS: We searched online databases (PubMed and ClinicalTrials.gov) and references of included articles. We included 25 articles describing 79 patients with RAS and flash oedema and seven articles describing 94 patients with RAS, CHF, and renal insufficiency. According to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system, the quality of the evidence was, at best, low. Seventy-six per cent of patients with flash oedema did not have any recurrence after angioplasty. Recurrence of symptoms was associated with either restenosis of the renal artery or cardiac arrhythmias in all patients. In the patients with CHF and renal insufficiency, the severity of heart failure symptoms, expressed as New York Heart Association (NYHA) functional class, improved after angioplasty in all included articles. CONCLUSION: The evidence included in this systematic review justifies a weak recommendation in favour of angioplasty in patients with atherosclerotic RAS and either flash pulmonary oedema or CHF and renal insufficiency. FAU - van den Berg, Danielle T N A AU - van den Berg DT AD - Department of Internal Medicine, Radboud University Nijmegen Medical Centre,PO Box 9101, 6500 HB, Nijmegen, The Netherlands. FAU - Deinum, Jaap AU - Deinum J FAU - Postma, Cornelis T AU - Postma CT FAU - van der Wilt, Geert Jan AU - van der Wilt GJ FAU - Riksen, Niels P AU - Riksen NP LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20120328 PL - England TA - Eur J Heart Fail JT - European journal of heart failure JID - 100887595 RN - AYI8EX34EU (Creatinine) SB - IM CIN - Eur J Heart Fail. 2012 Jul;14(7):716-7. PMID: 22685269 MH - *Angioplasty MH - Blood Pressure MH - Creatinine/blood MH - Heart Failure/*pathology/therapy MH - Humans MH - Pulmonary Edema/pathology/*therapy MH - Renal Artery Obstruction/pathology/*therapy MH - Renal Insufficiency/pathology EDAT- 2012/03/30 06:00 MHDA- 2012/11/07 06:00 CRDT- 2012/03/30 06:00 PHST- 2012/03/30 06:00 [entrez] PHST- 2012/03/30 06:00 [pubmed] PHST- 2012/11/07 06:00 [medline] AID - hfs037 [pii] AID - 10.1093/eurjhf/hfs037 [doi] PST - ppublish SO - Eur J Heart Fail. 2012 Jul;14(7):773-81. doi: 10.1093/eurjhf/hfs037. Epub 2012 Mar 28.