PMID- 22456049
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20221207
IS  - 2242-3982 (Electronic)
IS  - 1239-9736 (Print)
IS  - 1239-9736 (Linking)
VI  - 71
DP  - 2012 Mar 19
TI  - Level and temporal trend of perfluoroalkyl acids in Greenlandic Inuit.
PG  - 17998
LID - 10.3402/ijch.v71i0.17998 [doi]
AB  - OBJECTIVES: Perfluoroalkyl acids (PFAAs) have been detected in human blood, 
      breast milk and umbilical cord blood across the globe. PFAAs do accumulate in the 
      marine food chain in Arctic regions. In Greenland, increasing PFAA concentrations 
      were observed during 1982-2006 in ringed seals and polar bears. However, until 
      now, no data have been reported for PFAAs in Greenlandic Inuit. This study 
      assesses the level and temporal trend of serum PFAAs in Greenlandic Inuit. STUDY 
      DESIGN: Cross-section and temporal time trend survey. METHODS: Serum PFAA levels 
      were determined in 284 Inuit from different Greenlandic districts using liquid 
      chromatography-tandem mass spectrometry with electrospray ionization. The 
      temporal time trend of serum PFAAs in Nuuk Inuit during 1998-2005 and the 
      correlation between serum PFAAs and legacy persistent organic pollutants (POPs) 
      were explored. RESULTS: Serum PFAA levels were higher in Nuuk Inuit than in 
      non-Nuuk Inuit. Within the same district, higher PFAA levels were observed for 
      males. An age-dependent, increasing trend of serum PFAA levels in the period from 
      1998-2005 was observed for Nuuk Inuit. For the pooled gender data, no significant 
      association between PFAAs and legacy POPs was observed for Nuuk Inuit while for 
      non-Nuuk Inuit this correlation was significant. No correlation between PFAAs and 
      legacy POPs was found for male Inuit, whereas significant correlation was 
      observed both for pooled female Inuit and for non-Nuuk Inuit females. 
      CONCLUSIONS: We suggest that sources other than seafood intake might contribute 
      to the observed higher PFAA levels in Nuuk Inuit compared to the pooled non-Nuuk 
      Inuit.
FAU - Long, Manhai
AU  - Long M
AD  - Aarhus University, School of Public Health, Centre of Arctic Environmental 
      Medicine, Aarhus, Denmark.
FAU - Bossi, Rossana
AU  - Bossi R
FAU - Bonefeld-Jorgensen, Eva C
AU  - Bonefeld-Jorgensen EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120319
PL  - United States
TA  - Int J Circumpolar Health
JT  - International journal of circumpolar health
JID - 9713056
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Fluorocarbons)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alkanesulfonic Acids/blood
MH  - Caprylates/blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fluorocarbons/*blood
MH  - Greenland
MH  - Humans
MH  - *Inuit
MH  - Male
MH  - Middle Aged
MH  - Time Factors
MH  - Young Adult
PMC - PMC3417589
EDAT- 2012/03/30 06:00
MHDA- 2012/11/14 06:00
PMCR- 2012/01/01
CRDT- 2012/03/30 06:00
PHST- 2012/03/30 06:00 [entrez]
PHST- 2012/03/30 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 17998 [pii]
AID - IJCH-71-17998 [pii]
AID - 10.3402/ijch.v71i0.17998 [doi]
PST - epublish
SO  - Int J Circumpolar Health. 2012 Mar 19;71:17998. doi: 10.3402/ijch.v71i0.17998.