PMID- 22456954
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20211021
IS  - 1420-908X (Electronic)
IS  - 1023-3830 (Linking)
VI  - 61
IP  - 7
DP  - 2012 Jul
TI  - Immunological markers in allergic rhinitis patients treated with date palm 
      immunotherapy.
PG  - 719-24
LID - 10.1007/s00011-012-0464-4 [doi]
AB  - OBJECTIVE: Allergic rhinitis (AR) is regulated by the local production and 
      release of several cytokines. Allergen specific immunotherapy (IT) has been 
      widely used for many years as a specific treatment of allergic diseases. This 
      study aimed to investigate the changes in clinical and immunological markers 
      before and after Phoenix dactylifera IT in AR patients. MATERIALS AND METHODS: 
      Total symptom score and levels of total immunoglobulin E (IgE), albumin, 
      interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, IL-4, and 
      IL-13 were measured in the serum and nasal samples of thirty non-atopic healthy 
      controls and thirty patients with allergic rhinitis before and after 15 months of 
      IT. RESULTS: We found significantly higher concentrations of serum TNF-alpha and 
      nasal TNF-alpha and IL-13, and significantly lower concentration of nasal IL-10, in 
      allergic patients than in non-allergic. Moreover, serum and nasal IL-10 increased 
      significantly after IT. However, there was neither a significant reduction in 
      total IgE nor a significant increase in IFN-gamma at the end of IT. CONCLUSIONS: Our 
      data show a clinical improvement associated with a decline in some inflammation 
      parameters after IT. Moreover, date palm IT induced a significant increase in 
      serum and nasal IL-10 levels.
FAU - Boghdadi, Ghada
AU  - Boghdadi G
AD  - Immunology Research Lab, Faculty of Medicine, Microbiology and Immunology, 
      Zagazig University, Zagazig, Egypt. gsboghdadi@zu.edu.eg
FAU - Marei, Ayman
AU  - Marei A
FAU - Ali, Atef
AU  - Ali A
FAU - Lotfy, Gamal
AU  - Lotfy G
FAU - Abdulfattah, Magdi
AU  - Abdulfattah M
FAU - Sorour, Samir
AU  - Sorour S
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120329
PL  - Switzerland
TA  - Inflamm Res
JT  - Inflammation research : official journal of the European Histamine Research 
      Society ... [et al.]
JID - 9508160
RN  - 0 (Albumins)
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Albumins/immunology
MH  - Allergens/immunology
MH  - Arecaceae/*immunology
MH  - Cytokines/blood/immunology
MH  - Desensitization, Immunologic
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Nasal Mucosa/immunology
MH  - Plant Extracts/immunology
MH  - Pollen/*immunology
MH  - Rhinitis, Allergic, Seasonal/blood/immunology/*therapy
MH  - Skin Tests
MH  - Young Adult
EDAT- 2012/03/30 06:00
MHDA- 2012/10/17 06:00
CRDT- 2012/03/30 06:00
PHST- 2011/08/09 00:00 [received]
PHST- 2012/03/08 00:00 [accepted]
PHST- 2012/01/25 00:00 [revised]
PHST- 2012/03/30 06:00 [entrez]
PHST- 2012/03/30 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - 10.1007/s00011-012-0464-4 [doi]
PST - ppublish
SO  - Inflamm Res. 2012 Jul;61(7):719-24. doi: 10.1007/s00011-012-0464-4. Epub 2012 Mar 
      29.