PMID- 22457004
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20221207
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 33
IP  - 2
DP  - 2013 Feb
TI  - Association of MMP-3 (-1612 5A/6A) polymorphism with knee osteoarthritis in Thai 
      population.
PG  - 435-9
LID - 10.1007/s00296-012-2371-y [doi]
AB  - Osteoarthritis (OA) is a degenerative joint disorder resulting in destruction of 
      articular cartilage, osteophyte formation, and subchondral bone sclerosis. In 
      recent years, numerous genetic factors have been identified and implicated in 
      causing osteoarthritis. One such genetic defect is a single nucleotide 
      polymorphism at position -1612 of matrix metalloproteinase-3 (MMP-3) promoter 
      region, known to lead to three possible genotypes, 5A/5A, 6A/6A, and 5A/6A. The 
      purpose of this study was to investigate the association of MMP-3 -1612 5A/6A 
      gene polymorphism with knee osteoarthritis in Thai population. Genotype 
      distributions and allelic frequencies of MMP-3 -1612 5A/6A polymorphism were 
      investigated in 200 participants (100 patients with knee osteoarthritis and 100 
      healthy controls). Genotyping was performed using polymerase chain 
      reaction-restriction fragment length polymorphism. There was no statistically 
      significant difference between the groups with respect to genotype distribution 
      (P > 0.05). The 5A allele frequency was indicated as 15.5 %, and 6A allele was as 
      84.5 % in OA patients, whereas it was 10-90 % in the control group. Accordingly, 
      the present study has indicated that the -1612 5A/6A polymorphism genotypes of 
      MMP-3 gene promoter do not play a role in the development of osteoarthritis in 
      the Thai population.
FAU - Honsawek, Sittisak
AU  - Honsawek S
AD  - Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, 
      Bangkok 10330, Thailand. Sittisak.H@chula.ac.th
FAU - Malila, Somkiat
AU  - Malila S
FAU - Yuktanandana, Pongsak
AU  - Yuktanandana P
FAU - Tanavalee, Aree
AU  - Tanavalee A
FAU - Deepaisarnsakul, Benjamad
AU  - Deepaisarnsakul B
FAU - Parvizi, Javad
AU  - Parvizi J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120329
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Osteoarthritis, Knee/enzymology/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
EDAT- 2012/03/30 06:00
MHDA- 2013/08/06 06:00
CRDT- 2012/03/30 06:00
PHST- 2011/09/09 00:00 [received]
PHST- 2012/03/11 00:00 [accepted]
PHST- 2012/03/30 06:00 [entrez]
PHST- 2012/03/30 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - 10.1007/s00296-012-2371-y [doi]
PST - ppublish
SO  - Rheumatol Int. 2013 Feb;33(2):435-9. doi: 10.1007/s00296-012-2371-y. Epub 2012 
      Mar 29.