PMID- 22457282
OWN - NLM
STAT- MEDLINE
DCOM- 20120629
LR  - 20191210
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 205
IP  - 10
DP  - 2012 May 15
TI  - Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of 
      immunocompetent individuals.
PG  - 1539-43
LID - 10.1093/infdis/jis237 [doi]
AB  - Specific mutations within the hypervariable herpes simplex virus (HSV) gene 
      thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the 
      existence of latent ACV-resistant (ACV(R)) HSV-1, we determined the genetic and 
      functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia 
      (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a 
      donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV(S)) and 
      multiple phylogenetic-related minor ACV(S) and ACV(R) TK variants. Contrary to 
      minor variants, major TK variants were shared between paired TG. The data 
      demonstrate the coexistence of phylogenetic-related ACV(S) and ACV(R) latent 
      HSV-1 in human TG.
FAU - van Velzen, Monique
AU  - van Velzen M
AD  - Department of Virology, Laboratory of Neuro-Oncology and Clinical and Cancer 
      Proteomics, Erasmus Medical Center, The Netherlands.
FAU - van Loenen, Freek B
AU  - van Loenen FB
FAU - Meesters, Roland J W
AU  - Meesters RJ
FAU - de Graaf, Miranda
AU  - de Graaf M
FAU - Remeijer, Lies
AU  - Remeijer L
FAU - Luider, Theo M
AU  - Luider TM
FAU - Osterhaus, Albert D M E
AU  - Osterhaus AD
FAU - Verjans, Georges M G M
AU  - Verjans GM
LA  - eng
SI  - GENBANK/HQ667768
SI  - GENBANK/HQ667769
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SI  - GENBANK/HQ686038
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120328
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antiviral Agents)
RN  - 0 (DNA, Viral)
RN  - EC 2.7.1.21 (Thymidine Kinase)
RN  - X4HES1O11F (Acyclovir)
SB  - IM
MH  - Acyclovir/*pharmacology
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Antiviral Agents/*pharmacology
MH  - Autopsy
MH  - Base Sequence
MH  - COS Cells
MH  - Chlorocebus aethiops
MH  - DNA, Viral/genetics
MH  - Drug Resistance, Viral/genetics
MH  - Female
MH  - Herpes Simplex/drug therapy/*virology
MH  - Herpesvirus 1, Human/drug effects/*genetics/physiology
MH  - Humans
MH  - Immunocompetence
MH  - Male
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phylogeny
MH  - Prevalence
MH  - Sequence Analysis, DNA
MH  - Thymidine Kinase/chemistry/*genetics/metabolism
MH  - Trigeminal Ganglion/*virology
MH  - Virus Latency
EDAT- 2012/03/30 06:00
MHDA- 2012/06/30 06:00
CRDT- 2012/03/30 06:00
PHST- 2012/03/30 06:00 [entrez]
PHST- 2012/03/30 06:00 [pubmed]
PHST- 2012/06/30 06:00 [medline]
AID - jis237 [pii]
AID - 10.1093/infdis/jis237 [doi]
PST - ppublish
SO  - J Infect Dis. 2012 May 15;205(10):1539-43. doi: 10.1093/infdis/jis237. Epub 2012 
      Mar 28.