PMID- 22457329
OWN - NLM
STAT- MEDLINE
DCOM- 20120808
LR  - 20240109
IS  - 1937-9145 (Electronic)
IS  - 1945-0877 (Linking)
VI  - 5
IP  - 217
DP  - 2012 Mar 27
TI  - Phospholipase D and mTORC1: nutrients are what bring them together.
PG  - pe13
LID - 10.1126/scisignal.2003019 [doi]
AB  - Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) plays a central role in 
      translating nutrient abundance into cell growth and proliferation. Although 
      specific proteins have been described as mediators of this nutrient input, their 
      mechanistic linkage remains incomplete. Two studies have added phospholipase D 
      (PLD) as a mediator of nutrients to mTORC1. Furthermore, these studies link PLD 
      and its product phosphatidic acid to previously identified activators of mTORC1 
      signaling, including the class III phosphoinositide-3 kinase, and provide 
      evidence of the existence of two parallel nutrient-regulated pathways that 
      converge on mTORC1 at late endosomes and/or lysosomes.
FAU - Wiczer, Brian M
AU  - Wiczer BM
AD  - Department of Internal Medicine, Division of Hematology/Oncology, Metabolic 
      Diseases Institute, University of Cincinnati, Cincinnati, OH 45237, USA.
FAU - Thomas, George
AU  - Thomas G
LA  - eng
GR  - T32 CA117846/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20120327
PL  - United States
TA  - Sci Signal
JT  - Science signaling
JID - 101465400
RN  - 0 (CRTC1 protein, human)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.1.137 (Class III Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.1.4.4 (Phospholipase D)
RN  - EC 3.1.4.4 (phospholipase D1)
SB  - IM
MH  - Animals
MH  - Class III Phosphatidylinositol 3-Kinases/metabolism
MH  - Humans
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Models, Biological
MH  - Multiprotein Complexes/metabolism
MH  - Nutritional Physiological Phenomena
MH  - Phospholipase D/*metabolism
MH  - Proteins/*metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Transcription Factors/*metabolism
EDAT- 2012/03/30 06:00
MHDA- 2012/08/09 06:00
CRDT- 2012/03/30 06:00
PHST- 2012/03/30 06:00 [entrez]
PHST- 2012/03/30 06:00 [pubmed]
PHST- 2012/08/09 06:00 [medline]
AID - scisignal.2003019 [pii]
AID - 10.1126/scisignal.2003019 [doi]
PST - epublish
SO  - Sci Signal. 2012 Mar 27;5(217):pe13. doi: 10.1126/scisignal.2003019.