PMID- 22457418
OWN - NLM
STAT- MEDLINE
DCOM- 20130621
LR  - 20130117
IS  - 1941-2444 (Electronic)
IS  - 0148-6071 (Linking)
VI  - 37
IP  - 1
DP  - 2013 Jan
TI  - Influence of the slow infusion of a soybean oil emulsion on plasma cytokines and 
      ex vivo T cell proliferation after an esophagectomy.
PG  - 123-8
LID - 10.1177/0148607112442216 [doi]
AB  - BACKGROUND: Lipid emulsions have been suggested to reduce immune responses, 
      particularly in severely stressed patients. The authors investigated the 
      influence of the slow intravenous infusion of a soybean oil-based lipid emulsion 
      on some immune parameters in patients who had undergone an esophagectomy for 
      esophageal cancer. METHODS: Thirty-two patients who had undergone an 
      esophagectomy were randomly divided into a lipid emulsion (LPD)-treated group and 
      a control group. All patients received parenteral feeding with a glucose-based 
      solution. Patients in the LPD group received 100 mL of a 20% soybean oil emulsion 
      for 7 days after the esophagectomy in addition to the glucose-based feeding. A 
      slow infusion rate (0.09-0.12 g/kg/h) was adopted to take account of the 
      intrinsic degradation of infused lipids. Immune responses were measured based on 
      lymphocyte proliferation and serum concentrations of monocyte chemoattractant 
      protein-1 (MCP-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). The 
      authors also measured levels of rapid turnover proteins (ie, transferrin, 
      prealbumin, and retinol-binding protein). RESULTS: Phytohemagglutinin- and 
      concanavalin A-stimulated lymphocyte proliferation significantly decreased after 
      the esophagectomy, but no significant difference was seen between the LPD and 
      control groups. No significant difference in changes in plasma concentrations of 
      MCP-1, IL-6 and TNF-alpha occurred between the 2 groups either. Plasma concentrations 
      of rapid turnover proteins did not differ between the groups. CONCLUSIONS: These 
      results indicate that the lipid emulsion did not affect the immune parameters 
      measured in patients who had undergone an esophagectomy when administered at a 
      slow rate.
FAU - Kagawa, Yoshiyuki
AU  - Kagawa Y
AD  - Department of Clinical Pharmaceutics, University of Shizuoka, Shizuoka, Japan. 
      kagaway@u-shizuoka-ken.ac.jp
FAU - Maeda, Toshio
AU  - Maeda T
FAU - Kato, Yasuhiro
AU  - Kato Y
FAU - Ueda, Iori
AU  - Ueda I
FAU - Kudo, Tomoko
AU  - Kudo T
FAU - Watanabe, Naoe
AU  - Watanabe N
FAU - Kimura, Midori
AU  - Kimura M
FAU - Minami, Sato
AU  - Minami S
FAU - Sakamoto, Tatsuichiro
AU  - Sakamoto T
FAU - Yamada, Hiroshi
AU  - Yamada H
FAU - Takagi, Masakazu
AU  - Takagi M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120328
PL  - United States
TA  - JPEN J Parenter Enteral Nutr
JT  - JPEN. Journal of parenteral and enteral nutrition
JID - 7804134
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Fat Emulsions, Intravenous)
RN  - 0 (Interleukin-6)
RN  - 0 (Phytohemagglutinins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11028-71-0 (Concanavalin A)
RN  - 8001-22-7 (Soybean Oil)
SB  - IM
MH  - Aged
MH  - Cell Proliferation/drug effects
MH  - Chemokine CCL2/blood
MH  - Concanavalin A/immunology/pharmacology
MH  - Cytokines/*blood
MH  - Esophageal Neoplasms/surgery
MH  - *Esophagectomy
MH  - Esophagus/surgery
MH  - Fat Emulsions, Intravenous/*administration & dosage/chemistry/pharmacology
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - *Parenteral Nutrition
MH  - Phytohemagglutinins/immunology/pharmacology
MH  - Soybean Oil/*administration & dosage/chemistry/immunology/pharmacology
MH  - T-Lymphocytes/*drug effects
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2012/03/30 06:00
MHDA- 2013/06/25 06:00
CRDT- 2012/03/30 06:00
PHST- 2012/03/30 06:00 [entrez]
PHST- 2012/03/30 06:00 [pubmed]
PHST- 2013/06/25 06:00 [medline]
AID - 0148607112442216 [pii]
AID - 10.1177/0148607112442216 [doi]
PST - ppublish
SO  - JPEN J Parenter Enteral Nutr. 2013 Jan;37(1):123-8. doi: 
      10.1177/0148607112442216. Epub 2012 Mar 28.