PMID- 22457495
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 32
IP  - 13
DP  - 2012 Mar 28
TI  - A role for perirhinal cortex in memory for novel object-context associations.
PG  - 4473-81
LID - 10.1523/JNEUROSCI.5751-11.2012 [doi]
AB  - It is debated whether functional divisions between structures in the medial 
      temporal lobe (MTL), in particular the perirhinal cortex (PrC) and hippocampus 
      (HC), are best conceptualized according to memory process (Diana et al., 2007; 
      Ranganath, 2010; Wixted et al., 2010) or stimulus category (Graham et al., 2010). 
      In the former account, PrC is critical for item familiarity but not recollection 
      of associations between items and their contexts (which is instead dependent upon 
      the HC; Ranganath et al., 2004). In the latter theory, complex object 
      representations in PrC are capable of supporting memory for objects as well as 
      for object-context associations, particularly when there is a demand to 
      discriminate between highly visually similar objects (Cowell et al., 2010). To 
      adjudicate between these accounts, human participants were scanned while making 
      two different judgments about visually presented objects (is the object common or 
      uncommon, or does the object have more edges or curves). In a subsequent, 
      unscanned, retrieval phase, participants made item (old/new) followed by context 
      (encoding task) judgments about previously seen and novel objects. Neural 
      activity at encoding was separated according to the accuracy of the retrieval 
      judgments. PrC activity predicted successful item-context judgments, a result 
      that remained when item-memory strength was equated across objects for which the 
      context was remembered or forgotten. These data imply that the function of PrC 
      goes beyond processing item-based memory information, contributing additionally 
      to memory for item-context associations when the stimuli are objects (Graham et 
      al., 2010).
FAU - Watson, Hilary C
AU  - Watson HC
AD  - Wales Institute of Cognitive Neuroscience, Cardiff University, Cardiff CF10 3AT, 
      United Kingdom.
FAU - Wilding, Edward L
AU  - Wilding EL
FAU - Graham, Kim S
AU  - Graham KS
LA  - eng
GR  - G1002149/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Adult
MH  - Association Learning/*physiology
MH  - Brain Mapping/methods/*psychology
MH  - Female
MH  - Humans
MH  - Judgment/physiology
MH  - Magnetic Resonance Imaging/methods/psychology
MH  - Male
MH  - Memory/*physiology
MH  - Photic Stimulation/methods
MH  - Temporal Lobe/*physiology
MH  - Visual Perception/physiology
PMC - PMC6622046
EDAT- 2012/03/30 06:00
MHDA- 2012/05/19 06:00
PMCR- 2012/09/28
CRDT- 2012/03/30 06:00
PHST- 2012/03/30 06:00 [entrez]
PHST- 2012/03/30 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
PHST- 2012/09/28 00:00 [pmc-release]
AID - 32/13/4473 [pii]
AID - 3763866 [pii]
AID - 10.1523/JNEUROSCI.5751-11.2012 [doi]
PST - ppublish
SO  - J Neurosci. 2012 Mar 28;32(13):4473-81. doi: 10.1523/JNEUROSCI.5751-11.2012.