PMID- 22457502
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20220410
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 32
IP  - 13
DP  - 2012 Mar 28
TI  - Interaction of BDNF and COMT polymorphisms on paired-associative 
      stimulation-induced cortical plasticity.
PG  - 4553-61
LID - 10.1523/JNEUROSCI.6010-11.2012 [doi]
AB  - The common single-nucleotide polymorphism (SNP) brain-derived neurotrophic factor 
      (BDNF) valine-to-methionine substitution at codon 66 (Val66Met) has been 
      associated with differences in memory functions and cortical plasticity following 
      brain stimulation. Other studies could not confirm these results, though, and 
      potential interactions of BDNF carrier status with other learning-relevant SNPs 
      are largely unknown. The present study aimed to evaluate the effects of BDNF 
      Val66Met genotype on paired associative stimulation (PAS)-induced motor cortex 
      plasticity, while additionally taking catechol-O-methyltransferase (COMT) 
      Val158Met and kidney and brain (KIBRA) rs17070145 carrier status into account. 
      Therefore, a cohort of 2 x 16 age- and education-matched healthy young females 
      underwent transcranial magnetic stimulation using an excitatory PAS(25) protocol 
      to induce cortical plasticity. Cognitive performance was assessed using implicit 
      grammar- and motor-learning tasks and a detailed neuropsychological test battery. 
      While BDNF carrier status alone did not significantly influence PAS-induced 
      cortical plasticity, we found a significant BDNF x COMT interaction, showing 
      higher plasticity immediately following the PAS(25) protocol for the BDNF Val/Val 
      vs Met genotype in COMT Met homozygotes only (ANOVA, p = 0.027). A similar 
      advantage for this group was noted for implicit grammar learning (ANOVA, p = 
      0.021). Accounting for KIBRA rs17070145 did not explain significant variance. Our 
      findings for the first time demonstrate an interaction of BDNF by COMT on human 
      cortical plasticity. Moreover, they show that genotype-related differences in 
      neurophysiology translate into behavioral differences. These findings might 
      contribute to a better understanding of the mechanisms of interindividual 
      differences in cognition.
FAU - Witte, A Veronica
AU  - Witte AV
AD  - Department of Neurology, Charite-Universitatsmedizin Berlin, 10117 Berlin, 
      Germany.
FAU - Kurten, Julia
AU  - Kurten J
FAU - Jansen, Stefanie
AU  - Jansen S
FAU - Schirmacher, Anja
AU  - Schirmacher A
FAU - Brand, Eva
AU  - Brand E
FAU - Sommer, Jens
AU  - Sommer J
FAU - Floel, Agnes
AU  - Floel A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (WWC1 protein, human)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Catechol O-Methyltransferase/genetics/*physiology
MH  - Cerebral Cortex/*physiology
MH  - Cognition/physiology
MH  - Female
MH  - Genotype
MH  - Heterozygote
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/genetics/physiology
MH  - Learning/physiology
MH  - Neuronal Plasticity/genetics/*physiology
MH  - Neuropsychological Tests/statistics & numerical data
MH  - Phosphoproteins/genetics/physiology
MH  - Polymorphism, Single Nucleotide/*physiology
MH  - Psychomotor Performance/physiology
MH  - Transcranial Magnetic Stimulation/methods/*psychology
PMC - PMC6622078
EDAT- 2012/03/30 06:00
MHDA- 2012/05/19 06:00
PMCR- 2012/09/28
CRDT- 2012/03/30 06:00
PHST- 2012/03/30 06:00 [entrez]
PHST- 2012/03/30 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
PHST- 2012/09/28 00:00 [pmc-release]
AID - 32/13/4553 [pii]
AID - 3764863 [pii]
AID - 10.1523/JNEUROSCI.6010-11.2012 [doi]
PST - ppublish
SO  - J Neurosci. 2012 Mar 28;32(13):4553-61. doi: 10.1523/JNEUROSCI.6010-11.2012.