PMID- 22457677
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Print)
IS  - 1734-1922 (Linking)
VI  - 8
IP  - 1
DP  - 2012 Feb 29
TI  - Changes in left ventricular ejection fraction and coronary flow reserve after 
      coronary microembolization.
PG  - 63-9
LID - 10.5114/aoms.2012.27283 [doi]
AB  - INTRODUCTION: Although coronary microembolization (CME) is a frequent phenomenon 
      in patients undergoing percutaneous coronary intervention, few data are available 
      on the changes in left ventricular ejection fraction (LVEF) and coronary flow 
      reserve (CFR) after CME. MATERIAL AND METHODS: In this study, six miniature swine 
      of either sex (body weight 21-25 kg) were used to prepare a CME model. After 
      coronary angiography, 1.2 x 10(5) microspheres (42 microm) were selectively infused 
      into the left anterior descending artery via an infusion catheter. Left 
      ventricular ejection fraction was evaluated using transthoracic echocardiography; 
      myocardial blood flow was measured using coloured microspheres; and CFR and 
      coronary pressure were measured using Doppler and a pressure wire. RESULTS: Left 
      ventricular ejection fraction was 0.77 +/-0.08 at baseline, 0.69 +/-0.08 at 2 h, 0.68 
      +/-0.08 at 6 h, and 0.76 +/-0.06 at 1 week (2 h vs. baseline p < 0.05; 6 h vs. 
      baseline p < 0.01). After CME, left ventricular end systolic volume (LVESV) and 
      end diastolic volume (LVEDV) were significant larger 1 week later (p < 0.01 for 
      both), while CFR was significantly reduced at 6 h (1.24 +/-0.10 at 6 h vs. 1.77 
      +/-0.30 at baseline, p < 0.01) and myocardial blood flow remained unchanged. Serum 
      ET-1 level was significantly higher only at 6 h after CME (6 h vs. baseline p < 
      0.05). CONCLUSIONS: Reduction of CFR and LVEF is significant at 6 h after CME and 
      recovers 1 week later with left ventricular dilation.
FAU - Ma, Jianying
AU  - Ma J
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 
      Institute of Cardiovascular Disease, Shanghai, China.
FAU - Qian, Juying
AU  - Qian J
FAU - Ge, Junbo
AU  - Ge J
FAU - Zeng, Xin
AU  - Zeng X
FAU - Sun, Aijun
AU  - Sun A
FAU - Chang, Shufu
AU  - Chang S
FAU - Chen, Zhangwei
AU  - Chen Z
FAU - Zou, Yunzeng
AU  - Zou Y
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3309439
OTO - NOTNLM
OT  - coronary artery
OT  - left ventricular ejection fraction
OT  - microembolization
OT  - remodelling
EDAT- 2012/03/30 06:00
MHDA- 2012/03/30 06:01
PMCR- 2012/02/29
CRDT- 2012/03/30 06:00
PHST- 2010/08/27 00:00 [received]
PHST- 2010/10/22 00:00 [revised]
PHST- 2010/12/07 00:00 [accepted]
PHST- 2012/03/30 06:00 [entrez]
PHST- 2012/03/30 06:00 [pubmed]
PHST- 2012/03/30 06:01 [medline]
PHST- 2012/02/29 00:00 [pmc-release]
AID - 18213 [pii]
AID - 10.5114/aoms.2012.27283 [doi]
PST - ppublish
SO  - Arch Med Sci. 2012 Feb 29;8(1):63-9. doi: 10.5114/aoms.2012.27283.