PMID- 2245800
OWN - NLM
STAT- MEDLINE
DCOM- 19910109
LR  - 20190813
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 31
IP  - 6
DP  - 1990 Nov-Dec
TI  - Neonatal monosodium glutamate abolishes corticotropin-releasing factor-induced 
      epileptogenic activity in rats.
PG  - 708-12
AB  - Intracerebroventricular (i.c.v.) injection of rat corticotropin-releasing factor 
      (rCRF) at doses of 5-20 micrograms in rats induces epileptogenic activity 
      characterized by pacemaker-like spikes localized in the hippocampal leads. Such 
      an effect was still present in rats neonatally treated with saline but was absent 
      in those neonatally treated with monosodium glutamate (MSG), a treatment that 
      caused marked changes in the concentration of several brain neurotransmitters and 
      neuropeptides in hypothalamic nuclei where CRF is highly concentrated and is 
      believed to induce endocrinologic and behavioral effects. The present results 
      suggest the rCRF-induced spiking activity is mediated by activation of neuronal 
      pathways sensitive to MSG neurotoxic effect.
FAU - Marrosu, F
AU  - Marrosu F
AD  - Institute of Neurology, University of Cagliari, Italy.
FAU - Argiolas, A
AU  - Argiolas A
FAU - Carcangiu, P
AU  - Carcangiu P
FAU - Giagheddu, M
AU  - Giagheddu M
FAU - Fratta, W
AU  - Fratta W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - W81N5U6R6U (Sodium Glutamate)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*growth & development
MH  - Body Weight
MH  - *Corticotropin-Releasing Hormone/administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Electroencephalography
MH  - Epilepsy/*chemically induced/metabolism/prevention & control
MH  - Female
MH  - Frontal Lobe/drug effects/metabolism
MH  - Hypothalamus/drug effects/metabolism
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sodium Glutamate/administration & dosage/*pharmacology
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
AID - 10.1111/j.1528-1157.1990.tb05510.x [doi]
PST - ppublish
SO  - Epilepsia. 1990 Nov-Dec;31(6):708-12. doi: 10.1111/j.1528-1157.1990.tb05510.x.